Bioequivalence evaluation of two 5% ceftiofur hydrochloride sterile suspension in pigs

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成果类型：

期刊论文

作者：

Xiong, Jincheng;Zhu, Qianqian;Lei, Zhixin;Yang, Shuaike;Chen, Peiyuan;...

通讯作者：

Cao, Jiyue;Qiu, Yinsheng

作者机构：

[Zhu, Qianqian; Zhao, Yaxin; Lei, Zhixin; Xiong, Jincheng; Yang, Shuaike; Chen, Peiyuan; Cao, Jiyue] Huazhong Agr Univ, Dept Vet Pharmacol, Coll Vet Med, Wuhan 430070, Hubei, Peoples R China.

[Zhu, Qianqian; Zhao, Yaxin; Lei, Zhixin; Xiong, Jincheng; Yang, Shuaike; Cao, Jiyue] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

[Zhu, Qianqian; Zhao, Yaxin; Lei, Zhixin; Xiong, Jincheng; Yang, Shuaike; Cao, Jiyue] Huazhong Agr Univ, Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

[Qiu, Yinsheng] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Cao, Jiyue] H

[Qiu, Yinsheng] W

Huazhong Agr Univ, Dept Vet Pharmacol, Coll Vet Med, Wuhan 430070, Hubei, Peoples R China.

Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

Huazhong Agr Univ, Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

语种：

英文

关键词：

bioequivalence;ceftiofur;confidence interval;pharmacokinetic;pig

期刊：

Journal of Veterinary Medical Science

ISSN：

0916-7250

年：

2018

卷：

期：

页码：

1847-1852

DOI：

10.1292/jvms.18-0470

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31572572, 31601922]; Natural Science Foundation of Hubei Province, ChinaNatural Science Foundation of Hubei Province [2017CFB446]

机构署名：

本校为通讯机构

院系归属：

动物科学与营养工程学院

摘要：

The purpose of this study was to evaluate the bioequivalence of 5% ceftiofur hydrochloride sterile suspension in two formulations, a test formulation (Saifukang 5% CEF, Hvsen) and a reference formulation (Excenel®RTU 5% CEF, Pfizer). Twenty-four healthy pigs were assigned to a two-period, two-treatment crossover parallel trial, and both formulations were administered at a single intramuscular dose of 5 mg/kg weight, with a 7-day washout period. Blood samples were collected consecutively for up to 144 hr after administration. The concentrations...

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Bioequivalence evaluation of two 5% ceftiofur hydrochloride sterile suspension in pigs

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