Bioequivalence evaluation of two 5% ceftiofur hydrochloride sterile suspension in pigs

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成果类型：

期刊论文

作者：

Xiong, Jincheng;Zhu, Qianqian;Lei, Zhixin;Yang, Shuaike;Chen, Peiyuan;...

通讯作者：

Cao, Jiyue;Qiu, Yinsheng

作者机构：

[Zhu, Qianqian; Zhao, Yaxin; Lei, Zhixin; Xiong, Jincheng; Yang, Shuaike; Chen, Peiyuan; Cao, Jiyue] Huazhong Agr Univ, Dept Vet Pharmacol, Coll Vet Med, Wuhan 430070, Hubei, Peoples R China.

[Zhu, Qianqian; Zhao, Yaxin; Lei, Zhixin; Xiong, Jincheng; Yang, Shuaike; Cao, Jiyue] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

[Zhu, Qianqian; Zhao, Yaxin; Lei, Zhixin; Xiong, Jincheng; Yang, Shuaike; Cao, Jiyue] Huazhong Agr Univ, Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

[Qiu, Yinsheng] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Cao, Jiyue] H

[Qiu, Yinsheng] W

Huazhong Agr Univ, Dept Vet Pharmacol, Coll Vet Med, Wuhan 430070, Hubei, Peoples R China.

Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

Huazhong Agr Univ, Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.

语种：

英文

关键词：

antiinfective agent;ceftiofur;cephalosporin derivative;animal;clinical trial;crossover procedure;drug formulation;female;high performance liquid chromatography;male;metabolism;pig;therapeutic equivalence;veterinary medicine;Animals;Anti-Bacterial Agents;Cephalosporins;Chromatography, High Pressure Liquid;Cross-Over Studies;Drug Compounding;Female;Male;Swine;Therapeutic Equivalency

期刊：

Journal of Veterinary Medical Science

ISSN：

0916-7250

年：

2018

卷：

期：

页码：

1847-1852

DOI：

10.1292/jvms.18-0470

基金类别：

The work was supported by National Natural Science Foundation of China (grant No. 31572572, 31601922) and the Natural Science Foundation of Hubei Province, China (grant No. 2017CFB446).

机构署名：

本校为通讯机构

院系归属：

动物科学与营养工程学院

摘要：

The purpose of this study was to evaluate the bioequivalence of 5% ceftiofur hydrochloride sterile suspension in two formulations, a test formulation (Saifukang 5% CEF, Hvsen) and a reference formulation (Excenel®RTU 5% CEF, Pfizer). Twenty-four healthy pigs were assigned to a two-period, two-treatment crossover parallel trial, and both formulations were administered at a single intramuscular dose of 5 mg/kg weight, with a 7-day washout period. Blood samples were collected consecutively for up to 144 hr after administration. The concentrations...

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Bioequivalence evaluation of two 5% ceftiofur hydrochloride sterile suspension in pigs

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