Tilmicosin enteric granules and premix to pigs: Antimicrobial susceptibility testing and comparative pharmacokinetics.

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成果类型：

期刊论文

作者：

Xiong, Jincheng;Zhu, Qianqian;Zhao, Yaxin;Yang, Shuaike;Cao, Jiyue*;...

通讯作者：

Cao, Jiyue;Qiu, Yinsheng

作者机构：

[Zhu, Qianqian; Zhao, Yaxin; Xiong, Jincheng; Yang, Shuaike; Cao, Jiyue] Huazhong Agr Univ, Coll Vet Med, Dept Vet Pharmacol, Wuhan, Hubei, Peoples R China.

[Zhu, Qianqian; Xiong, Jincheng; Yang, Shuaike; Cao, Jiyue] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, Wuhan, Hubei, Peoples R China.

[Zhu, Qianqian; Xiong, Jincheng; Yang, Shuaike; Cao, Jiyue] Huazhong Agr Univ, Key Lab Detect Vet Drug Residues, Wuhan, Hubei, Peoples R China.

[Qiu, Yinsheng] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Hubei, Peoples R China.

通讯机构：

[Cao, Jiyue] H

[Qiu, Yinsheng] W

Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, Wuhan, Hubei, Peoples R China.

Huazhong Agr Univ, Key Lab Detect Vet Drug Residues, Wuhan, Hubei, Peoples R China.

Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Hubei, Peoples R China.

语种：

英文

关键词：

bioavailability;pharmacokinetics;pig;susceptibility;tilmicosin

期刊：

Journal of Veterinary Pharmacology and Therapeutics

ISSN：

0140-7783

年：

2019

卷：

期：

页码：

336-345

DOI：

10.1111/jvp.12753

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31572572, 31601922]; Natural Science Foundation of Hubei Province, ChinaNatural Science Foundation of Hubei Province [2017CFB446]

机构署名：

本校为通讯机构

院系归属：

动物科学与营养工程学院

摘要：

The purpose of this study was to compare the pharmacokinetics and relative bioavailability of tilmicosin enteric granules and premix after oral administration at a dose of 40 mg/kg in pigs. Three kinds of different respiratory pathogens were selected for determination of minimal inhibitory concentration (MIC) to tilmicosin. Eight healthy pigs were assigned to a two-period, randomized crossover design. A modified rapid, sensitive HPLC method was used for determining the concentrations of tilmicosin in plasma. Pharmacokinetic parameters were calculated by using WinNonlin 5.2 software. The MIC90 ...

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Tilmicosin enteric granules and premix to pigs: Antimicrobial susceptibility testing and comparative pharmacokinetics.

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