Tilmicosin enteric granules and premix to pigs: Antimicrobial susceptibility testing and comparative pharmacokinetics

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成果类型：

期刊论文

作者：

Xiong, Jincheng;Zhu, Qianqian;Zhao, Yaxin;Yang, Shuaike;Cao, Jiyue*;...

通讯作者：

Cao, Jiyue;Qiu, Yinsheng

作者机构：

[Zhu, Qianqian; Zhao, Yaxin; Xiong, Jincheng; Yang, Shuaike; Cao, Jiyue] Huazhong Agr Univ, Coll Vet Med, Dept Vet Pharmacol, Wuhan, Hubei, Peoples R China.

[Zhu, Qianqian; Xiong, Jincheng; Yang, Shuaike; Cao, Jiyue] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, Wuhan, Hubei, Peoples R China.

[Zhu, Qianqian; Xiong, Jincheng; Yang, Shuaike; Cao, Jiyue] Huazhong Agr Univ, Key Lab Detect Vet Drug Residues, Wuhan, Hubei, Peoples R China.

[Qiu, Yinsheng] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Hubei, Peoples R China.

通讯机构：

[Cao, Jiyue] H

[Qiu, Yinsheng] W

Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, Wuhan, Hubei, Peoples R China.

Huazhong Agr Univ, Key Lab Detect Vet Drug Residues, Wuhan, Hubei, Peoples R China.

Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Hubei, Peoples R China.

语种：

英文

关键词：

bioavailability;pharmacokinetics;pig;susceptibility;tilmicosin

期刊：

Journal of Veterinary Pharmacology and Therapeutics

ISSN：

0140-7783

年：

2019

卷：

期：

页码：

336-345

DOI：

10.1111/jvp.12753

基金类别：

This work was supported by the National Natural Science Foundation of China (Grant No. 31572572, 31601922) and the Natural Science Foundation of Hubei Province, China (Grant No. 2017CFB446). We thank the Huazhong Agricultural University for permission to conduct this study. National Natural Science Foundation of China, Grant/Award Number: 31572572 and 31601922; Natural Science Foundation of Hubei Province, China, Grant/Award Number: 2017CFB446

机构署名：

本校为通讯机构

院系归属：

动物科学与营养工程学院

摘要：

The purpose of this study was to compare the pharmacokinetics and relative bioavailability of tilmicosin enteric granules and premix after oral administration at a dose of 40 mg/kg in pigs. Three kinds of different respiratory pathogens were selected for determination of minimal inhibitory concentration (MIC) to tilmicosin. Eight healthy pigs were assigned to a two-period, randomized crossover design. A modified rapid, sensitive HPLC method was used for determining the concentrations of tilmicosin in plasma. Pharmacokinetic parameters were calculated by using WinNonlin 5.2 software. The MIC90 ...

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Tilmicosin enteric granules and premix to pigs: Antimicrobial susceptibility testing and comparative pharmacokinetics

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