Construction of multilayer multifunctional hydrogel microspheres with natural macromolecules, tannic acid, and copper for enhanced diabetic wound healing

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成果类型：

期刊论文

作者：

Chen, Zuhan;Jiang, Beizhi;Bi, Huanjing;Wang, Chongfeng;Liu, Yanyan;...

通讯作者：

Ding, XM;Xie, F

作者机构：

[Wang, Chongfeng; Niu, Zejiaxin; Wang, Ying; Dong, Boqing; Chen, Zuhan; Ma, Ruiyang; Bi, Huanjing; Wang, Jingwen; Ding, Xiaoming] Xi An Jiao Tong Univ, Nephropathy Hosp, Affiliated Hosp 1, Dept Kidney Transplantat, Xian 710061, Peoples R China.

[Xie, Fang; Jiang, Beizhi] Wuhan Polytech Univ, Natl R&D Ctr Se rich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Serich Agr Pro, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.

[Liu, Yanyan] Wuhan Univ, Zhongnan Hosp, Dept Gynaecol & Obstet, Wuhan 430071, Peoples R China.

[Yu, Xiaoyang] Xi An Jiao Tong Univ, Hosp Nephrol, Affiliated Hosp 1, Dept Nephrol, Xian 710061, Peoples R China.

通讯机构：

[Xie, F ] W

[Ding, XM ] X

Xi An Jiao Tong Univ, Nephropathy Hosp, Affiliated Hosp 1, Dept Kidney Transplantat, Xian 710061, Peoples R China.

Wuhan Polytech Univ, Natl R&D Ctr Se rich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Serich Agr Pro, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.

Wuhan Polytech Univ, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Hydrogel microsphere;Diabetic wound healing;Multilayer;Wound dressing;Multifunctional;Natural macromolecular

期刊：

Chemical Engineering Journal

ISSN：

1385-8947

年：

2025

卷：

520

页码：

165896

DOI：

10.1016/j.cej.2025.165896

基金类别：

National Natural Science Foundation of China [82370802, 82400935, 52303133]; Shaanxi Provincial Health Kidney Transplantation Research and Innovation Platform [2023PT-06]; Key Research and Development Program of Shaanxi Province [2023-YBSF-277]; Scientific Research Development Fund of the First Affiliated Hospital of Xi'an Jiaotong University [2022MS-03, 2022MS-08]

机构署名：

本校为通讯机构

院系归属：

硒科学与工程现代产业学院

摘要：

Diabetic wounds exhibit excessive local inflammation, oxidative stress, microcirculatory disorders, and an increased risk of infection, all of which contribute to delayed healing. The development of multifunctional wound dressings is therefore critical for effective diabetic wound management. This study successfully designed and fabricated multilayer multifunctional hydrogel microspheres (COQTCu) composed of methacrylated carboxymethyl chitosanc (CSMA), oxidized carboxymethyl starch (OCMS), quaternized chitin (QC), tannic acid (TA), and copper ions (Cu 2+ ). The microspheres were constructed u...

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Construction of multilayer multifunctional hydrogel microspheres with natural macromolecules, tannic acid, and copper for enhanced diabetic wound healing

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