This work was financially sponsored by NSFC (81902073), Key Laboratory of Animal Embryo Engineering and Molecular Breeding of Hubei Province (KLAEMB-2021-01) and Wuhan polytechnic university.
机构署名：
本校为第一且通讯机构
院系归属：
动物科学与营养工程学院
摘要：
Background: Host factors are required for Influenza virus infection and have great potential to become antiviral target. Objective: Here we demonstrate the role of TNK2 in influenza virus infection. CRISPR/Cas9 induced TNK2 deletion in A549 cells. Methods: CRISPR/Cas9-mediated deletion of TNK2. Western blotting and qPCR was used to measure the expression of TNK2 and other proteins. Results: CRISPR/Cas9-mediated deletion of TNK2 decreased the replication of influenza virus and significantly inhibited the ex-pression of viral proteins and TNK2 in...
