miR-122-5p Restrains Pancreatic Cancer Cell Growth and Causes Apoptosis by Negatively Regulating ASCT2

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成果类型：

期刊论文

作者：

Ren, Ping;Wu, Na;Fu, Shichen;Wang, Wenbin;Li, Qi;...

通讯作者：

Ren, P

作者机构：

[Li, Qi; Cheng, Qingzhou; Ren, Ping] Wuhan Polytech Univ, Coll Med & Hlth Sci, Wuhan, Peoples R China.

[Wu, Na] Hubei Coll Chinese Med, Sch Basic Med Sci, Jingzhou, Peoples R China.

[Fu, Shichen] Hubei Univ Sci & Technol, Sch Pharm, Xianning, Peoples R China.

[Wang, Wenbin] Jianghan Univ, Wuhan Hosp 6, Wuhan, Peoples R China.

[Ren, P; Ren, Ping] Wuhan Polytech Univ, Coll Med & Hlth Sci, 68 Xue Fu South Rd, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Ren, P ] W

Wuhan Polytech Univ, Coll Med & Hlth Sci, 68 Xue Fu South Rd, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

ASCT2;Pancreatic cancer;cell apoptosis;glutamine metabolism;miR-122-5p

期刊：

ANTICANCER RESEARCH

ISSN：

0250-7005

年：

2023

卷：

期：

页码：

4379-4388

DOI：

10.21873/anticanres.16634

基金类别：

This work was supported by the National Natural Science Foundation of China [grant number 81502635 (to Ping Ren)], Research Funding of Wuhan Polytechnic University [grant number 2022RZ001 (to Ping Ren)], the Health and Family Planning Commission of Hubei Province of China [grant number WJ2019M096 (to Wenbin Wang)], and Essential Science Indicators for subject construction projects of Wuhan Polytechnic University (to QINGZHOU CHENG)

机构署名：

本校为第一且通讯机构

院系归属：

医学与健康学院

摘要：

Background/Aim: System ASC amino acid transporter-2 (ASCT2) is abnormally highly expressed in tumor cells and closely associated with a poor prognosis, but the regulatory mechanism of abnormally high ASCT2 expression is scarcely investigated. MicroRNAs (miRNAs) that are abnormally expressed regulate gene expression to have either oncogenic or tumor-suppressive effects in pancreatic cancer (PC). MicroRNA-122-5p (miR-122-5p) dysregulation has been seen in various cancer entities, but the biological function of miR-122-5p in PC and its regulation ...

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miR-122-5p Restrains Pancreatic Cancer Cell Growth and Causes Apoptosis by Negatively Regulating ASCT2

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