Bayesian Benchmark Dose Assessment of Per- and Polyfluorinated Substances Exposure-Associated Thyroid Function Disruption During Pregnancy

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成果类型：

期刊论文

作者：

Li, Shiwen;Li, Jingguang;Wu, Yongning;Liu, Xin;Zhang, Lei

通讯作者：

Liu, X;Zhang, L

作者机构：

[Wu, Yongning; Li, Shiwen; Liu, Xin] Wuhan Polytech Univ, Coll Food Sci & Engn, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Peoples R China.

[Li, Jingguang; Wu, Yongning; Zhang, Lei] Chinese Acad Med Sci, Peking Union Med Coll, Dept Nutr & Food Safety, Res Unit Food Safety, Beijing 100010, Peoples R China.

[Li, Jingguang; Wu, Yongning; Zhang, Lei] China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Beijing 100010, Peoples R China.

[Zhang, Lei] China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Room 203,7 Pan Jiayuannanli, Beijing 10002, Peoples R China.

[Liu, Xin] Wuhan Polytech Univ, 68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Zhang, L ] C

[Liu, X ] W

Wuhan Polytech Univ, 68 Xuefu South Rd, Wuhan 430023, Hubei, Peoples R China.

China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Room 203,7 Pan Jiayuannanli, Beijing 10002, Peoples R China.

语种：

英文

关键词：

Benchmark dose;PFASs exposure;Pregnant women;Thyroid homeostasis

期刊：

Food and Chemical Toxicology

ISSN：

0278-6915

年：

2025

卷：

201

页码：

115456

DOI：

10.1016/j.fct.2025.115456

基金类别：

National Key Research and Development Program of China [2022YFF1102500]; National Natural Science Foundation of China [21976046]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Epidemiological evidence on maternal thyroid function disruption by prenatal exposure to perfluorinated and polyfluorinated substances (PFASs) is limited and inconsistent. The study examined the effects of PFASs exposure during early pregnancy on maternal thyroid function [free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroid peroxidase antibodies (TPOAb) and FT4/TSH ratio]. The associations were evaluated using both single and mixed pollutant models, statistical analyses were further utilized in benchmark dose (BMD) estimations to o...

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Bayesian Benchmark Dose Assessment of Per- and Polyfluorinated Substances Exposure-Associated Thyroid Function Disruption During Pregnancy

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