METTL14 facilitates the process of sexual reversal via m6A RNA methylation in Pelodiscus sinensis

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成果类型：

期刊论文

作者：

Tong Zhou;Guobin Chen;Jizeng Cao;Huizi Ji;Guiwei Zou;...

通讯作者：

Hongwei Liang

作者机构：

[Tong Zhou; Guobin Chen; Guiwei Zou; Hongwei Liang] Yangtze River Fisheries Research Institute, Chinese Academy of Fisheries Science, Wuhan 430223, China

College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China

Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430223, China

[Jizeng Cao] Yangtze River Fisheries Research Institute, Chinese Academy of Fisheries Science, Wuhan 430223, China<&wdkj&>College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China

[Huizi Ji] Yangtze River Fisheries Research Institute, Chinese Academy of Fisheries Science, Wuhan 430223, China<&wdkj&>Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430223, China

通讯机构：

[Hongwei Liang] Y

Yangtze River Fisheries Research Institute, Chinese Academy of Fisheries Science, Wuhan 430223, China

语种：

英文

关键词：

METTL14;Pelodiscus sinensis;RNA methylation;Sexual reversal

期刊：

Genomics

ISSN：

0888-7543

年：

2025

页码：

111030

DOI：

10.1016/j.ygeno.2025.111030

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

The Chinese soft-shelled turtle ( Pelodiscus sinensis ) demonstrates noteworthy sexual dimorphism, where the males grow more rapidly and significantly larger than females under equivalent conditions. Estradiol (E2) administration can catalyze transformation from male to pseudo-female (PF), during which m6A RNA methylation undergoes considerable alterations. Nevertheless, the function of m6A methylation, specifically, the methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit gene ( METTL14 ) during this sex reversal process remains unclear. Within this study, we characteriz...

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METTL14 facilitates the process of sexual reversal via m6A RNA methylation in Pelodiscus sinensis

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