Glutamine and glutaminolysis are required for efficient replication of infectious spleen and kidney necrosis virus in Chinese perch brain cells

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Fu, Xiaozhe;Hu, Xianqin;Li, Ningqiu*;Zheng, Feifei;Dong, Xingxing;...

通讯作者：

Li, Ningqiu;Lin, Li

作者机构：

[Li, Ningqiu; Lin, Qiang; Fu, Xiaozhe; Huang, Zhibin] Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Aquat Anim Immune Technol,Minist Agr, Key Lab Aquat Anim Immune Technol Guangdong Prov, Guangzhou 510380, Guangdong, Peoples R China.

[Dong, Xingxing; Zhao, Lijuan; Tu, Jiagang; Li, Ningqiu; Lin, Qiang; Duan, Jing; Fu, Xiaozhe; Lin, Li; Hu, Xianqin; Zheng, Feifei; Su, Jianguo; Li, NQ; Lin, L] Huazhong Agr Univ, Coll Fisheries Freshwater Aquaculture Collaborat, Res Ctr Marine Biol, Dept Aquat Anim Med, Wuhan 430070, Hubei, Peoples R China.

[Hu, Xianqin] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430023, Hubei, Peoples R China.

[Fu, Xiaozhe; Su, Jianguo] Northwest A&F Univ, Coll Anim Sci & Technol, Shanxi Key Lab Mol Biol Aquaculture, Yangling 712100, Peoples R China.

[Lin, Li] Hainan Univ, Coll Marine Sci, Hainan Prov Key Lab Trop Hydrobiol & Biotechnol, State Key Lab Marine Resource Utilizat South Chin, Haikou 570228, Peoples R China.

通讯机构：

[Li, Ningqiu] C

[Li, NQ; Lin, L; Lin, Li] H

Chinese Acad Fishery Sci, Pearl River Fisheries Res Inst, Key Lab Aquat Anim Immune Technol,Minist Agr, Key Lab Aquat Anim Immune Technol Guangdong Prov, Guangzhou 510380, Guangdong, Peoples R China.

Huazhong Agr Univ, Coll Fisheries Freshwater Aquaculture Collaborat, Res Ctr Marine Biol, Dept Aquat Anim Med, Wuhan 430070, Hubei, Peoples R China.

Hainan Univ, Coll Marine Sci, Hainan Prov Key Lab Trop Hydrobiol & Biotechnol, State Key Lab Marine Resource Utilizat South Chin, Haikou 570228, Peoples R China.

语种：

英文

关键词：

siniperca chuatsi;ISKNV;glutamine;glutaminolysis;TCA cycle

期刊：

Oncotarget

ISSN：

1949-2553

年：

2017

卷：

期：

页码：

2400-2412

DOI：

10.18632/oncotarget.13681

基金类别：

National Natural Science FundNational Natural Science Foundation of China (NSFC) [31502201, 31572657, 31372563]; Administration of Ocean and Fisheries of Guangdong Province [A201501B12, A201512C003, 2015-006, 2015-115]; Hubei Province [2015BBA228]; National Key Technology RD ProgramNational Key Technology R&D Program [2012BAD25B02]; Wuhan Science and Technology Bureau [2016020101010089]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2014PY035]

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

Viruses rely on host cellular metabolism for energy and macromolecule synthesis during their replication. Infectious spleen and kidney necrosis virus (ISKNV) causes significant economic losses in the Chinese perch (Siniperca chuatsi) industry worldwide. However, little is known about the relationship between ISKNV replication and cellular metabolism. Using transcriptomic analysis, we observed that glutamine metabolism in Chinese perch brain (CPB) cells is altered during ISKNV infection. Moreover, ISKNV replication was decreased in CPB cells cultured in the glutamine-depleted medium. ISKNV repl...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Glutamine and glutaminolysis are required for efficient replication of infectious spleen and kidney necrosis virus in Chinese perch brain cells

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问