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2,4-Dinitrotoluene (2,4-DNT) exposure induces liver developmental damage and perturbs lipid metabolism and oxygen transport gene expression in zebrafish (Danio rerio)

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成果类型:
期刊论文
作者:
Su, Liangxia;Sha, Hang;Liu, Jun;Yu, Le;Li, Huanhuan;...
通讯作者:
Wang, R
作者机构:
[Su, Liangxia; Wang, Rui; Liu, Jun; Yu, Le; Li, Huanhuan] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430023, Peoples R China.
[Sha, Hang] Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China.
通讯机构:
[Wang, R ] W
Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430023, Peoples R China.
语种:
英文
关键词:
2,4-dinitrotoluene;Lipid metabolism;Liver;Oxygen transport;Zebrafish
期刊:
Environmental Science and Pollution Research
ISSN:
0944-1344
年:
2023
卷:
30
期:
30
页码:
76104-76111
基金类别:
This work was supported by the National Natural Science Foundation of China (Grant No. 31201983) and Fujian Key Laboratory of Special Aquatic Formula Feed (No. TMKJZ2102).
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
2,4-Dinitrotoluene (2, 4-DNT) is a common environmental pollutant. The toxic effect on mammals of 2,4-DNT has been well studied, but its toxicity on aquatic organisms is little known. In this study, 126 healthy female zebrafish (Danio rerio) were exposed to different concentrations of 2,4-DNT (0, 2, 4, 8, 12 and 16mg/L) to determine 96-h semi-lethal concentrations (LC50). And then, 90 female zebrafish were exposed to 0, 2, 4 and 8mg/L 2,4-DNT for 5days to study liver toxicity. Exposed zebrafish developed hypoxia features, such as floating head ...

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