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Dual-Targeting and Multimodal Imaging-Guided Photothermal/Chemodynamic Synergistic Therapy Boosted by Ascorbic Acid-Induced H2O2in Situ Self-Supply

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成果类型:
期刊论文
作者:
Liu, Yang;Zhao, Yi;Li, Haimei;Zhang, Xiaoyang;Wang, Zichen;...
通讯作者:
Jiang, P.;Liu, Y.
作者机构:
[She, Wenyan; Jiang, Fenglei; Wang, Zichen; Liu, Yi; Jiang, Peng; Zhao, Yi; Zhang, Xiaoyang; Liu, Yang] Wuhan Univ, Coll Chem & Mol Sci, P, R China, Wuhan 430072, Peoples R China.
[She, Wenyan; Jiang, Fenglei; Wang, Zichen; Liu, Yi; Jiang, Peng; Zhao, Yi; Zhang, Xiaoyang; Liu, Yang] Zhongnan Hosp Wuhan Univ, Wuhan Univ, Sch Pharmaceut Sci, Dept Orthoped Trauma & Microsurg, R China, Wuhan 430072, Peoples R China.
[Jiang, Peng; Liu, Yang] Wuhan Univ, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Wuhan 430071, Peoples R China.
[Jiang, Peng; Liu, Yang] Hubei Jiangxia Lab, Wuhan 430200, Peoples R China.
[Liu, Yi; Li, Haimei] Wuhan Univ Sci & Technol, Key Lab Coal Convers & New Carbon Mat Hubei Prov, Wuhan 430081, Peoples R China.
通讯机构:
[Yi Liu; Peng Jiang] C
College of Chemistry and Molecular Sciences & School of Pharmaceutical Sciences, Department of Orthopedics Trauma and Microsurgery (Zhongnan Hospital of Wuhan University), Wuhan University, Wuhan 430072, P. R. China<&wdkj&>Key Laboratory of Coal Conversion and New Carbon Materials of Hubei Province & Institute of Advanced Materials and Nanotechnology, College of Chemical and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, P. R. China<&wdkj&>School of Chemical and Environmental Engineering, Wuhan Polytechnic University, Wuhan 430023, P. R. China<&wdkj&>College of Chemistry and Molecular Sciences & School of Pharmaceutical Sciences, Department of Orthopedics Trauma and Microsurgery (Zhongnan Hospital of Wuhan University), Wuhan University, Wuhan 430072, P. R. China<&wdkj&>Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University, Wuhan 430071, P. R. China<&wdkj&>Hubei Jiangxia Laboratory, Wuhan 430200, P. R. China
语种:
英文
关键词:
dual-targeted;chemodynamic therapy;multimodal imaging;ascorbic acid;tumor therapy
期刊:
ACS Applied Materials & Interfaces
ISSN:
1944-8244
年:
2023
卷:
15
期:
7
页码:
9841–9852
基金类别:
This research was supported by the National Natural Science Foundation of China (22073070 and 22074113), the Young Top-Notch Talent Cultivation Program of Hubei Province, the Science and Technology Plans of Tianjin (22ZYJDSS00070), and the Large-Scale Instrument and Equipment Sharing Foundation of Wuhan University (LF20221381). The authors would like to acknowledge the Center for Electron Microscopy at Wuhan University for their substantial support by providing JEM-F200 and JEM-2010FEF.
机构署名:
本校为其他机构
院系归属:
化学与环境工程学院
摘要:
Tumor-specific targeting and tumor visualization are major obstacles for clinical diagnosis and treatment. Herein, a dual-targeted "all-in-one" nanoplatform (FAA@CM) for trimodal imaging-guided photothermal/chemodynamic synergistic therapy was successfully synthesized by encapsulating Fe(3)O(4), Ag(2)S, and ascorbic acid with the 4T1 cell membrane. The dual-targeting capability derived from 4T1 cell membrane cloaking and magnetic targeting enables the highly precise tumor-specific delivery of FAA@CM. Fe(2+) released from FAA@CM in a weakly acid...

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