Innovative 3D microfluidic intestinal organoid model for assessing cadmium bioavailability in food: implications for enhanced exposure risk assessment

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成果类型：

期刊论文

作者：

Li, Yan;Sun, Wen;Wang, Qiao;Shi, Wan;Chen, Yu;...

通讯作者：

Guo, Xiao;Liu, Xin;Wu, YN

作者机构：

[Li, Yan; Sun, Wen] Sinopharm Anim Hlth Corp Ltd, Key Lab Anim Biol Prod & Genet Engn, Minist Agr & Rural, Wuhan 430023, Peoples R China.

[Li, Yan; Sun, Wen] China Natl Biotec Grp Co Ltd, State Key Lab Novel Vaccines Emerging Infect Dis, Beijing 100024, Peoples R China.

[Gong, Zhiyong; Wu, Yongning; Wang, Qiao; Liu, Xin; Guo, Xiao; Shi, Wan] Wuhan Polytech Univ, Coll Food Sci & Engn, Key Lab Deep Proc Major Grain & Oil, Chinese Minist Educ, Wuhan 430023, Peoples R China.

[Chen, Yu] Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha 410008, Peoples R China.

[Wu, Yongning] China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China.

通讯机构：

[Liu, X; Guo, X; Wu, YN ] W

Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Planar Transwell model;3D intestinal organoid model;Physiological relevance;Cd bioavailability

期刊：

食品科学与人类健康(英文)

ISSN：

2097-0765

年：

2025

卷：

期：

DOI：

10.26599/FSHW.2024.9250364

基金类别：

National key research and development program of China [2022YFF1102500]

机构署名：

本校为通讯机构

院系归属：

食品科学与工程学院

摘要：

Given the severe toxicity and widespread presence of cadmium (Cd) in staple foods such as rice, accurate dietary exposure assessments are imperative for public health. In vitro bioavailability is commonly used to adjust dietary exposure levels of risk factors; however, traditional planar Transwell models have limitations, such as cell dedifferentiation and lack of key intestinal components, necessitating a more physiologically relevant in vitro platform. This study introduces an innovative three-dimensional (3D) intestinal organoid model using a microfluidic chip to evaluate Cd bioavailability...

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Innovative 3D microfluidic intestinal organoid model for assessing cadmium bioavailability in food: implications for enhanced exposure risk assessment

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