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Dietary conjugated linoleic acid modulates morphology, selective immune parameters, and gene expressions in the intestine of grass carp

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成果类型:
期刊论文
作者:
Kong, Long;Cheng, Shi-yan;Xiang, Xiao-jun;Liu, Wen-shu;Yu, Deng-hang;...
通讯作者:
Dong, Gui-Fang
作者机构:
[Cheng, Shi-yan; Kong, Long; Huang, Feng; Dong, Gui-Fang; Xiang, Xiao-jun; Yu, Deng-hang] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.
[Liu, Wen-shu] Jiangxi Acad Agr Sci, Inst Anim Husb & Vet, Nanchang 330200, Jiangxi, Peoples R China.
[Yang, Yan-ou] Anhui Agr Univ, Coll Anim Sci & Technol, Hefei 230000, Anhui, Peoples R China.
[Zhou, Jiancheng] Wuhan DBN Aquaculture Technol Co Ltd, Wuhan 430090, Hubei, Peoples R China.
通讯机构:
[Dong, Gui-Fang] W
Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.
语种:
英文
关键词:
Conjugated linoleic acid;Ctenopharyngodon idella;Immune responses;Intestinal morphology;TLR4/NF-kappaB signaling pathway
期刊:
Fish & Shellfish Immunology
ISSN:
1050-4648
年:
2019
卷:
86
页码:
536-548
基金类别:
The authors wish to thank Qiang Yu, Jiwei, Peng, Dian, Yang for their assistance in the experiment. This study was supported by the National Natural Science Foundation of China (grant no. 31672666 , 31302195 ), the Natural Science Foundation of Hubei Province of China (grant no. 2016CFB389 ), Educational Commission of Hubei Province (grant no. D20151705 ), and Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety . We would like to thank Pei Zhang and An-na Du from the Core Facility and Technical Support, Wuhan Institute of Virology, for their help with producing TEM micrographs. Thanks are also given to the anonymous reviewers for their helpful suggestions.
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
Conjugated linoleic acid (CLA) has been shown to exhibit anti-inflammatory properties in the intestine in mammals. However, the effect of CLA on intestinal immune response in fish is still unknown. Therefore, a 65-day growth trial was conducted to investigate the effects of dietary conjugated linoleic acid (CLA) on morphology, selective immune parameters, and gene expressions in the intestine of grass carp. Seven isonitrogenous and isolipidic diets were formulated as follows: 0 (control), 0.5 (CLA0.5), 1 (CLA1), 1.5 (CLA1.5), 2 (CLA2), 2.5 (CLA...

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