期刊论文

中文

中国生物化学与分子生物学报

1007-7626

2003

19

6

683-689

10.3969/j.issn.1007-7626.2003.06.001

国家自然科学基金

本校为第一机构

极低密度脂蛋白受体(VLDL-R)属于低密度脂蛋白受体(LDL-R)超家族,结构上与LDL-R极为相似,而在结合特性、组织分布及生理功能上存在较大的差异.近年来的研究表明,VLDL-R配体结合域中的重复序列参与配体的结合,并已初步确定受体N端的4个重复序列中含有与配体结合的重要位点;在哺乳动物体内,VLDL-R主要分布于脂代谢活跃的组织细胞,如:心肌、骨骼肌和脂肪组织等,表明其与脂质尤其是甘油三酯的代谢密切相关;动脉粥样硬化(AS)的病变斑块组织中该受体的表达量很高,推测VLDL-R参与了AS的病变过程;在不同的细胞内,VLDL-R及其亚型的表达并不一致,并发现与各种生理、病理变化相关,已经发现多种转录因子参与...

Very low density lipoprotein receptor(VLDL\|R) belongs to the superfamily of low density lipoprotein receptor (LDL\|R) with similar gene and protein structure, but with obvious difference in receptor's binding characteristic, tissue distribution, physiological significance. Recent years, studies have shown that the ligand\|binding repeats(LBR) in the receptor's ligand\|binding domain contained important ligand\|binding site, especially for the first four LBRs at the N\|terminal of the receptor. In mammalia, VLDL\|R was found distributing in metabolism\|active tissues, such as heart, skeletal m...