Identification and Functional Analysis of Lysine 2-Hydroxyisobutyrylation in Cyanobacteria

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成果类型：

期刊论文

作者：

Li, Qiaoya;Lin, Jian;Ma, Haiyan;Yuan, Li;Liu, Xin;...

通讯作者：

Yang, Mingkun;Ge, F

作者机构：

[Yuan, Li; Lin, Jian; Xiong, Jie; Li, Qiaoya; Ge, Feng; Yang, Mingkun; Yang, MK; Ma, Haiyan] Chinese Acad Sci, Inst Hydrobiol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Wuhan 430072, Peoples R China.

[Yuan, Li; Lin, Jian; Xiong, Jie; Li, Qiaoya; Ge, Feng; Yang, Mingkun; Yang, MK; Ma, Haiyan; Miao, Wei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

[Liu, Xin] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Wuhan 430070, Peoples R China.

通讯机构：

[Ge, F ; Yang, MK] C

Chinese Acad Sci, Inst Hydrobiol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Wuhan 430072, Peoples R China.

Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

语种：

英文

关键词：

Synechococcus;cyanobacteria;glutaredoxin (Grx);lysine 2-hydroxyisobutyrylation (Khib);post-translational modification

期刊：

JOURNAL OF PROTEOME RESEARCH

ISSN：

1535-3893

年：

2024

DOI：

10.1021/acs.jproteome.3c00843

基金类别：

National Natural Science Foundation of China [32261133523, 32202910]; National Natural Science Foundation of China [2023AFB575]; HuBei Provincial Natural Science Foundation

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

Cyanobacteria are the oldest prokaryotic photoautotrophic microorganisms and have evolved complicated post-translational modification (PTM) machinery to respond to environmental stress. Lysine 2-hydroxyisobutyrylation (Khib) is a newly identified PTM that is reported to play important roles in diverse biological processes, however, its distribution and function in cyanobacteria have not been reported. Here, we performed the first systematic studies of Khib in a model cyanobacterium Synechococcus sp. strain PCC 7002 (Syn7002) using peptide prefractionation, pan-Khib antibody enrichment, and hig...

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Identification and Functional Analysis of Lysine 2-Hydroxyisobutyrylation in Cyanobacteria

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