Anti-liver fibrosis effects of the total flavonoids of litchi semen on CCl4-induced liver fibrosis in rats associated with the upregulation of retinol metabolism

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成果类型：

期刊论文

作者：

Yan, Jiongyi;Feng, Yinyi;Fang, Xuewan;Cui, Xiaojuan;Xia, Xing;...

通讯作者：

Jianqin Liang<&wdkj&>Jianfang Feng<&wdkj&>Kai Yu

作者机构：

[Xia, Xing; Luo, Weisheng; Yan, Jiongyi; Li, Fang; Feng, Yinyi; Liang, Jianqin; Feng, Jianfang; Fang, Xuewan; Cui, Xiaojuan] Guangxi Univ Chinese Med, Coll Pharm, Nanning, Peoples R China.

[Yan, Jiongyi] Wuzhou Vocat Coll, Sch Hlth, Wuzhou, Peoples R China.

[Yu, Kai] Guangxi Univ, Coll Anim Sci & Technol, Nanning, Peoples R China.

[Feng, Yinyi] Guangxi Med Univ, Affiliated Hosp 6, Yulin, Peoples R China.

[Liang, Jianqin; Feng, Jianfang] Natl Engn Res Ctr Mfg Technol Tradit Chinese Med, South China Branch, Nanning, Peoples R China.

通讯机构：

[Jianqin Liang; Jianfang Feng; Kai Yu] C

College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China<&wdkj&>College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China<&wdkj&>College of Animal Science and Technology, Guangxi University, Nanning, China

语种：

英文

关键词：

9-Cis-retinoic acid;iTRAQ;liver disease;RXRα;traditional Chinese medicine

期刊：

Pharmaceutical Biology

ISSN：

1388-0209

年：

2022

卷：

期：

页码：

1264-1277

DOI：

10.1080/13880209.2022.2086584

基金类别：

This study was supported by the National Natural Science Foundation of China under Grant Number [81960872]; Innovation-Driven Development Project of Guangxi under Grant number [GUIKE AA17202035]; Graduate Education Innovation Program of Guangxi University of Chinese Medicine under Grant number [YCXJ2021012]; Young and Middle Teachers’ Basic Ability Improvement Project of Guangxi under Grant number [2022KY1500]; and Guangxi Science and Technology Base and Talent Project under Grant number [GUIKE AD20238058].

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摘要：

Context: The litchi semen are traditional medications for treating liver fibrosis (LF) in China. The mechanism remains unclear. Objective: This study investigates the anti-liver fibrotic mechanism of the total flavonoids of litchi semen (TFL). Materials and methods: Sprague-Dawley rats with carbon tetrachloride-induced LF were treated with TFL (50 and 100 mg/kg) for 4 weeks. The anti-liver fibrotic effects of TFL were evaluated and the underlying mechanisms were investigated via histopathological analysis, proteomic analysis and molecular biolo...

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Anti-liver fibrosis effects of the total flavonoids of litchi semen on CCl4-induced liver fibrosis in rats associated with the upregulation of retinol metabolism

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