Dihydromyricetin alleviates ETEC K88-induced intestinal inflammatory injury by inhibiting quorum sensing-related virulence factors

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成果类型：

期刊论文

作者：

Shi, Yaqian;Liu, Jin;Zhou, Hualin;Wu, Zhongyuan;Qiu, Yinsheng;...

通讯作者：

Wu, ZY

作者机构：

[Shi, Yaqian; Ye, Chun; Liu, Jin; Qiu, Yinsheng; Wu, Zhongyuan; Wu, ZY] Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Peoples R China.

[Shi, Yaqian; Ye, Chun; Liu, Jin; Qiu, Yinsheng; Wu, Zhongyuan; Wu, ZY] Wuhan Polytech Univ, Wuhan Engn & Technol Res Ctr Anim Dis Resistant Nu, Sch Anim Sci & Nutr Engn, Wuhan, Peoples R China.

[Zhou, Hualin] Xiangyang Polytech, Agr Coll, Xiangyang, Peoples R China.

通讯机构：

[Wu, ZY ] W

Wuhan Polytech Univ, Sch Anim Sci & Nutr Engn, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Peoples R China.

Wuhan Polytech Univ, Wuhan Engn & Technol Res Ctr Anim Dis Resistant Nu, Sch Anim Sci & Nutr Engn, Wuhan, Peoples R China.

语种：

英文

关键词：

Dihydromyricetin;ETEC;Quorum sensing;Virulence factor;Intestinal inflammation

期刊：

BMC Microbiology

ISSN：

1471-2180

年：

2025

卷：

期：

页码：

1-14

DOI：

10.1186/s12866-025-03879-8

基金类别：

This study was supported by the Key Research and Development Plan of Hubei Province, China (grant no. 2023BBB069) and the National Natural Science Foundation of China (grant no. 32002333).

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is responsible for piglet diarrhea and causes substantial economic loss in the pig industry. Along with the restriction of antibiotics, natural compounds targeting bacterial virulence factors are supposed to be efficacious and attractive alternatives for controlling ETEC infection. This study aimed to investigate the influence of dihydromyricetin (DMY), a natural flavonoid compound, on the expression of virulence factors of ETEC and intestinal inflammatory injury. RESULTS: DMY interfered with ...

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Dihydromyricetin alleviates ETEC K88-induced intestinal inflammatory injury by inhibiting quorum sensing-related virulence factors

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