Acute and subacute toxicity studies on triptolide and triptolide-loaded polymeric micelles following intravenous administration in rodents

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成果类型：

期刊论文

作者：

Xu, Lingyun;Qiu, Yinsheng;Xu, Huibi;Ao, Wuliji*;Lam, Waikei;...

通讯作者：

Ao, Wuliji

作者机构：

[Xu, Lingyun] Wuhan Polytech Univ, Coll Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China.

[Qiu, Yinsheng] Wuhan Polytech Univ, Coll Anim Sci & Nutr Engn, Wuhan 430023, Peoples R China.

[Xu, Lingyun; Xu, Huibi; Ao, Wuliji; Yang, Xiangliang] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China.

[Lam, Waikei; Yang, Xiangliang] Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.

通讯机构：

[Ao, Wuliji] H

Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China.

语种：

英文

关键词：

Acute and subacute toxicity;Triptolide;Triptolide-loaded polymeric micelles

期刊：

Food and Chemical Toxicology

ISSN：

0278-6915

年：

2013

卷：

页码：

371-379

DOI：

10.1016/j.fct.2013.03.044

基金类别：

This work was supported by the National Basic Research Program of China (Grant No. 2012CB932500 ), the Science and Technology Planning Project from Hubei Provincial Department of Education (Grant No. B20101705 ) and the Science and Technology Development Fund of Macau Special Administration Region (Grant No. 040/2009/A2 ). We thank Prof. Shiqi Zhou and Feng Xiao for their technical assistance.

机构署名：

本校为第一机构

院系归属：

生命科学与技术学院

动物科学与营养工程学院

摘要：

Except its anti-tumour effects, triptolide (TP) also shows multiple pharmacological side activities, such as immune-suppressive and male anti-fertility. To increase the therapeutic index of TP, a novel polymeric micelle system containing TP (TP-PM) has been developed to treat tumour. Our previous studies have demonstrated the good anti-tumour efficacy of TP-PM. This paper investigated the acute toxicity in mice and subacute toxicity in rats of TP-PM and TP. Results demonstrated that the LD50 for TP-PM and TP administered intravenously were 1.06...

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Acute and subacute toxicity studies on triptolide and triptolide-loaded polymeric micelles following intravenous administration in rodents

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