期刊论文

Effects of Rosiglitazone and Bisphenol A Diglycidyl Ether on White Blood Cell Differential Count and Blood Biochemical Indexes of Weaned Piglets with Lipopolysaccharide Challenge

中文

动物营养学报

1006-267X

2010

22

1

145-150

10.3969/j.issn.1006-267x.2010.01.022

国家自然科学基金面上项目（30500362和30972109） 教育部科学技术研究重点项目（209082）

本校为第一机构

试验研究了过氧化物酶体增殖物激活受体γ(PPARγ)的激动剂和抑制剂对脂多糖(LPS)应激断奶仔猪白细胞分类计数和血液生化指标的影响.选取24头健康断奶仔猪,分为4组,每组6个重复,每个重复1头猪.4个组分别为:对照组;LPS组;罗格列酮(ROS,PPARγ激动剂)+LPS组;双酚A型环氧树脂(BADGE,PPARγ抑制剂)+ROS+LPS组.注射LPS或生理盐水3 h后,前腔静脉采血待测.结果显示:1)ROS缓解了LPS导致的断奶仔猪血液白细胞总数和淋巴细胞数量的降低(P

The experiment was conducted to investigate the effects of PPARγ, agonist or antagonist on white blood cell differential count and blood biochemical indexes of weaned piglets with lipopolysaccharide （LPS） challenge. Twenty-four weaned piglets were allotted to 4 groups （6 replicates per group and 1 piglet each replicate）, including control group, LPS group, rosiglitazone （ROS, PPARγ, agonist） ＋ LPS group and bisphenol A diglycidyl ether （BADGE, PPAR γ antagonist） ＋ ROS ＋ LPS group. Blood samples were collected at 3 h post-challenge...