期刊论文

Effects of Asparagine on Growth Performance and Toll-Like Receptor 4 and Nucleotide Binding Oligomerization Domain Signaling Pathways of Hypothalamus-Pituitary-Adrenal Axis of Weaned Piglets Challenged by Lipopolysaccharide

中文

动物营养学报

1006-267X

2018

30

12

5089-5098

10.3969/j.issn.1006-267x.2018.12.037

湖北省教育厅科学研究计划指导性项目(B2016076) 湖北省教育厅优秀中青年科技创新团队项目(T201508)。

本校为第一机构

本试验旨在研究天冬酰胺( Asn)对脂多糖( LPS)刺激断奶仔猪生长性能和下丘脑-垂体-肾上腺( HPA)轴的Toll样受体4( TLR4)和核苷酸结合寡聚化结构域( NOD)信号通路关键基因mRNA表达的影响.试验选取24头健康的( 21 ± 2)日龄“杜×长×大”断奶仔猪[( 8. 12 ± 0.56) kg],按体重相近原则随机分为4组,分别为: 1)对照组(基础饲粮) ; 2) LPS组(基础饲粮+LPS) ; 3) LPS+0.5% Asn组(基础饲粮+0.5%Asn+LPS) ; 4) LPS +1.0% Asn组(基础饲粮+ 1.0% Asn+LPS) .每组6个重复,每个重复1头猪.试验第20天,LPS组、LPS+0.5% Asn组和 LPS+1.0% Asn组的试验猪注射100 μg /kg BW的LPS,对照组试验猪则注射等量的生理盐...

This study was conducted to investigate the effects of asparagine (Asn) on growth performance and key gene mRNA expression in toll like receptor 4 ( TLR4) and nucleotide binding oligomerization domain (NOD) signal pathways of the hypothalamus-hypophysis-adrenal (HPA) axis of weaned piglets challenged by lipopolysaccharide ( LPS) . Twenty-four healthy ( 21 ± 2)-old-day weaning piglets ( Duroc × Landrace ×Yorkshire) with a body weight of (8.12+0.56) kg were selected and randomly divided into 4 groups: 1) control group ( basal diet) ,2) LPS gro...