期刊论文

Effects of Lentinan on Expression of Inflammation and Protein Degradation-Related Genes in Muscle of Weaned Piglets Challenged by Lipopolysaccharide

中文

动物营养学报

1006-267X

2020

32

3

1327-1333

10.3969/j.issn.1006-267x.2020.03.040

武汉市应用基础前沿项目（2018020401011304）；

本校为第一机构

本试验的目的是探究香菇多糖(LNT)对脂多糖(LPS)刺激断奶仔猪肌肉组织炎症反应及蛋白质降解相关基因表达的影响。试验选取24头体重(7.84±0.21) kg的健康三元杂交断奶仔猪,按照体重近似原则随机分为2组:对照组(12头)和香菇多糖组(12头) 。对照组饲喂基础饲粮,香菇多糖组饲喂基础饲粮+0.02%香菇多糖。饲喂28 d后,每组选6头猪腹膜注射100 μg/kg BW的LPS,剩下的6头则等量注射0.9%生理盐水,4 h后将仔猪麻醉、屠宰,取肌肉样品检测Toll样受体4(TLR4) 、核苷酸结合寡聚化结构域(NOD)以及丝氨酸/苏氨酸蛋白激酶(Akt)/叉头转录因子(FOXO)信号通路相关基因mRNA表达量。结果显示:1)注射LPS后,仔猪TLR4、骨...

This experiment was conducted to investigate the effects of lentinan (LNT) on the expression of inflammation and protein degradation-related genes in muscle of weaned piglets challenged by lipopolysaccharide (LPS). Twenty-four healthy weaned piglets with the body weight of (7.84±0.21) kg were randomly divided into 2 groups According to the similar body weight principle: control group (n = 12) and LNT group (n = 12). Weaned piglets in the control group were fed a basal diet, and those in LNT group were fed the basal diet+ 0.02% LNT. After feedi...