期刊论文

Liu, Y.

中文

动物营养学报

1006-267X

2022

34

4

2606-2612

10.3969/j.issn.1006-267x.2022.04.054

国家自然科学基金面上项目（31772615）；

本校为第一且通讯机构

本试验旨在研究脂多糖（LPS）刺激对断奶仔猪空肠形态结构、炎症反应和程序性坏死信号通路相关基因表达的影响。选取12头平均体重为（7.07±0.57） kg的28日龄杜×长×大三元断奶仔猪，随机分为2组，分别为对照组和LPS刺激组，每组6头。预饲9 d后，LPS组腹腔注射100μg/kg BW的LPS，对照组注射等量的生理盐水。LPS注射4 h后将所有仔猪麻醉屠宰，取空肠样品待测。结果表明：与对照组相比，LPS刺激后仔猪空肠绒毛严重萎缩，并大量脱落，绒毛高度和隐窝深度显著降低（P＜0.05）；空肠黏膜RNA/DNA显著下降（P＜0.05），蛋白质含量和蛋白质/DNA有显著下降趋势（P=0.054、P=0.095）；空肠炎性细胞因子...

The aim of this study was to investigate the effects of lipopolysaccharide (LPS) challenge on jejunal morphology, inflammatory response and necroptosis signaling pathway related gene expression of weaned pig⁃ lets. Twenty weaned piglets with the average body of (7.1±0.9) kg and aged 28 days were randomly divided into 2 groups including control group and LPS challenge group, and each group had 6 piglets. Afer 9 day of preliminary feeding, the piglets in the LPS challenge group were treated with intraperitoneal injection of 100 μg / kg BW LPS,...