Functional human 3D microvascular networks on a chip to study the procoagulant effects of ambient fine particulate matter(Open Access)

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成果类型：

期刊论文

作者：

Li, Yan;Pi, Qing-Meng;Wang, Peng-Cheng;Liu, Lie-Ju;Han, Zheng-Gang;...

通讯作者：

Wu, Yang;Yang, Xu

作者机构：

[Wu, Yang; Li, Yan; Wang, Peng-Cheng; Gong, Zhi-Yong] Wuhan Polytech Univ, Coll Food Sci & Engn, Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Hubei, Peoples R China.

[Yang, Xu] Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.

[Pi, Qing-Meng] MIT, Harvard MIT Div Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA.

[Li, Yan] Yale Univ, Sch Engn & Appl Sci, Dept Biomed Engn, New Haven, CT 06520 USA.

[Pi, Qing-Meng] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Orthoped Surg, Shanghai 200233, Peoples R China.

通讯机构：

[Wu, Yang] W

[Yang, Xu] C

Wuhan Polytech Univ, Coll Food Sci & Engn, Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Hubei, Peoples R China.

Cent China Normal Univ, Coll Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.

语种：

英文

期刊：

RSC Advances

ISSN：

2046-2069

年：

2017

卷：

期：

页码：

56108-56116

DOI：

10.1039/c7ra11357a

基金类别：

National Natural Science Foundation of China [21607117]

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

生命科学与技术学院

摘要：

Exposure to ambient fine particulate matter (FPM) has been thought to be associated with cardiovascular disease. However, the pathogenesis remains largely unknown. Animal models have been widely used in toxicological research, but species difference makes it impossible to directly translate discoveries from animals to humans. In this study, we developed a 3D functional human microvascular network in a microfluidic device. The established model enables endothelial cells to form vessel-like microtissues and have physiological functions which are closer to cells in human blood vessels. The perfus...

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Functional human 3D microvascular networks on a chip to study the procoagulant effects of ambient fine particulate matter(Open Access)

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