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Functional human 3D microvascular networks on a chip to study the cytocompatibility of alpha-MnO2 nanowire

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成果类型:
期刊论文、会议论文
作者:
Li, Yan;Wang, Pengcheng;Gong, Zhiyong;Wu, Yang*;Yang, Xu*
通讯作者:
Wu, Yang;Yang, Xu
作者机构:
[Li, Yan; Wang, Pengcheng] Wuhan Polytech Univ, Key Lab Deep Proc Major Grain & Oil, Minist Educ, Coll Food Sci & Engn, Wuhan, Hubei, Peoples R China.
[Wu, Yang; Gong, Zhiyong] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Coll Food Sci & Engn, Wuhan, Hubei, Peoples R China.
[Yang, Xu] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Coll Life Sci, Wuhan, Hubei, Peoples R China.
通讯机构:
[Wu, Yang] W
[Yang, Xu] C
Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Coll Food Sci & Engn, Wuhan, Hubei, Peoples R China.
Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Coll Life Sci, Wuhan, Hubei, Peoples R China.
语种:
英文
关键词:
3D cell cuture;MnO2 nanowires;oxidative stress;vascular toxicity
期刊:
Ferroelectrics
ISSN:
0015-0193
年:
2019
卷:
546
期:
1
页码:
13-24
会议名称:
Joint Symposium of the 9th International Conference of th Chinese-Society-of-Micro-Nano-Technology (CSMNT) / Microsystems and Nanoengineering Summit (MAN)
会议时间:
AUG 17-20, 2018
会议地点:
Hohhot, PEOPLES R CHINA
会议主办单位:
[Li, Yan;Wang, Pengcheng] Wuhan Polytech Univ, Key Lab Deep Proc Major Grain & Oil, Minist Educ, Coll Food Sci & Engn, Wuhan, Hubei, Peoples R China.^[Gong, Zhiyong;Wu, Yang] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Coll Food Sci & Engn, Wuhan, Hubei, Peoples R China.^[Yang, Xu] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Coll Life Sci, Wuhan, Hubei, Peoples R China.
会议赞助商:
Chinese Soc Micro Nano Technol, China SocMat Res, Youth Work Comm, Tianjin Univ
出版地:
2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
出版者:
TAYLOR & FRANCIS LTD
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21607117]
机构署名:
本校为第一且通讯机构
院系归属:
食品科学与工程学院
摘要:
A 3D functional human microvascular network in a microfluidic device was developed in this study. The established model enables endotheilal cells to form vessel-like microtissues and behave physiological functions which are closer to cells in human blood vessels. It provides a possible bridge for how the research outcomes translate to humans. The ɑ-MnO2 nanowires, which were successfully synthesized using the hydrothermal approach. The vascular toxicity was evaluated based on this organotypic 3D microvessel model. Our results demonstrated that...

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