Baicalin Inhibits Haemophilus Parasuis-Induced High-Mobility Group Box 1 Release during Inflammation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Fu, Shulin;Liu, Huashan;Chen, Xiao;Qiu, Yinsheng*;Ye, Chun;...

通讯作者：

Qiu, Yinsheng

作者机构：

[Hu, Chien-An Andy; Liu, Huashan; Liu, Yu; Hou, Yongqing; Ye, Chun; Chen, Xiao; Qiu, Yinsheng; Wu, Zhongyuan; Fu, Shulin; Guo, Ling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

[Liu, Huashan; Liu, Yu; Hou, Yongqing; Ye, Chun; Chen, Xiao; Qiu, Yinsheng; Wu, Zhongyuan; Fu, Shulin; Guo, Ling] Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Wuhan 430023, Hubei, Peoples R China.

[Hu, Chien-An Andy] Univ New Mexico, Sch Med, Biochem & Mol Biol, Albuquerque, NM 87131 USA.

通讯机构：

[Qiu, Yinsheng] W

[Qiu, Yinsheng] H

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.

Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

baicalin;Haemophilus parasuis;HMGB1;RNA-Seq;inflammation

期刊：

International Journal of Molecular Sciences

ISSN：

1661-6596

年：

2018

卷：

期：

DOI：

10.3390/ijms19051307

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31572572, 31601922]; Natural Science Foundation of Hubei Province, ChinaNatural Science Foundation of Hubei Province [2017CFB446]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Haemophilus parasuis (H. parasuis) can cause Glässer’s disease in pigs. However, the molecular mechanism of the inflammation response induced by H. parasuis remains unclear. The high-mobility group box 1 (HMGB1) protein is related to the pathogenesis of various infectious pathogens, but little is known about whether H. parasuis can induce the release of HMGB1 in piglet peripheral blood monocytes. Baicalin displays important anti-inflammatory and anti-microbial activities. In the present study, we investigated whether H. parasuis can trigger t...

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Baicalin Inhibits Haemophilus Parasuis-Induced High-Mobility Group Box 1 Release during Inflammation

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