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Polydiacetylene-based poly-ion complex enabling aggregation-induced emission and photodynamic therapy dual turn-on for on-demand pathogenic bacteria elimination

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成果类型:
期刊论文
作者:
Tian, Sidan;Lu, Yuan;He, Zhenyan;Yue, Qiang;Zhuang, Zhiyong;...
通讯作者:
Liang Luo
作者机构:
[Meng, Fanling; Zhuang, Zhiyong; Lu, Yuan; Luo, Liang; Tian, Sidan; Yue, Qiang; He, Zhenyan] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Natl Engn Res Ctr Nanomed, Wuhan 430074, Peoples R China.
[Luo, Liang] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Key Lab Mol Biophys, Minist Educ, Wuhan 430074, Peoples R China.
[Luo, Liang] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Hubei Key Lab Bioinorgan Chem & Mat Med, Wuhan 430074, Peoples R China.
[Wang, Yingzhou] Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan 430023, Peoples R China.
通讯机构:
[Liang Luo] N
National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China<&wdkj&>Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China<&wdkj&>Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China
语种:
英文
关键词:
poly-ion complex;ROS responsive;polydiacetylene;photodynamic therapy;aggregation-induced emission
期刊:
中国科学:化学英文版
ISSN:
1674-7291
年:
2022
卷:
65
期:
9
页码:
1782-1790
基金类别:
supported by the National Natural Science Foundation of China (21877042, 22077038, 22107032); the National Basic Research Plan of China (2018YFA0208903); Postdoctoral Research Foundation of China (2017M622454, 2020T130038ZX); Huazhong University Startup Fund;
机构署名:
本校为其他机构
院系归属:
生命科学与技术学院
摘要:
Poly-ion complex (PIC) integrating non-antibiotic theranostics holds great promise in the combat against drug-resistant bacteria. Photosensitizers with aggregation-induced emission (AIE) characteristic are particularly intriguing theranostic agents, but incorporating them into antibacterial PIC to enable both fluorescence and reactive oxygen species (ROS) generation turn-on deems a great challenge. Here we report the development of a PIC that can dually boost the fluorescence and ROS generation in the presence of pathogen bacteria. The PIC is c...

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