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Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs

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成果类型:
期刊论文
作者:
Wang, Dan;Kuang, Yanling;Lv, Qingqing;Xie, Wenshuai;Xu, Xiao;...
通讯作者:
Yulan Liu
作者机构:
[Xu, Xiao; Liu, Yulan; Wang, Dan; Xie, Wenshuai; Lv, Qingqing; Kuang, Yanling; Zhu, Huiling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.
[Zhang, Yue; Cong, Xin] Enshi Se Run Mat Engn Technol Co Ltd, Enshi 445000, Peoples R China.
[Cheng, Shuiyuan] Wuhan Polytech Univ, Natl R&D Ctr Serich Agr Prod Proc, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China.
通讯机构:
[Yulan Liu] H
Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan, China
语种:
英文
关键词:
MFN2;intestine;mitochondrial fusion;piglets;selenium;sepsis
期刊:
中国科学:生命科学(英文版)
ISSN:
1674-7305
年:
2023
卷:
66
期:
9
页码:
2099-2111
基金类别:
National Natural Science Foundation of China [U22A20517, 32272906, 32102566]; Project of Wuhan Science and Technology Bureau [2022020801010391]
机构署名:
本校为第一机构
院系归属:
动物科学与营养工程学院
硒科学与工程现代产业学院
摘要:
Sepsis is a life-threatening organ dysfunction caused by the dysregulated response of the host to an infection, and treatments are limited. Recently, a novel selenium source, selenium-enriched Cardamine violifolia (SEC) has attracted much attention due to its anti-inflammatory and antioxidant properties, but little is known about its role in the treatment of sepsis. Here, we found that SEC alleviated LPS-induced intestinal damage, as indicated by improved intestinal morphology, and increased disaccharidase activity and tight junction protein ex...

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