6:2 Chlorinated Polyfluoroalkyl Ether Sulfonates Exert Stronger Thyroid Homeostasis Disruptive Effects in Newborns than Perfluorooctanesulfonate: Evidence Based on Bayesian Benchmark Dose Values from a Population Study

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Xin;Zhang, Lei;Liu, Jiaying;Zaya, Gerili;Wang, Yuxin;...

通讯作者：

Zhang, L;Liu, JY

作者机构：

[Liu, Xin] Wuhan Polytech Univ, Coll Food Sci & Engn, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Peoples R China.

[Li, Jingguang; Wu, Yongning; Liu, Xin; Zhang, Lei; Wang, Yuxin] Chinese Acad Med Sci 2019RU014, China Natl Ctr Food Safety Risk Assessment CFSA, Res Unit Food Safety, NHC Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China.

[Zaya, Gerili] Chinese Ctr Dis Control & Prevent, Natl Inst Occupat Hlth & Poison Control, Beijing 100050, Peoples R China.

[Xiang, Qian] Univ Elect Sci & Technol China, Sichuan Peoples Hosp, Sichuan Acad Med Sci, Healthcare Associated Infect Control Ctr, Chengdu 610072, Peoples R China.

[Liu, Jiaying] China Agr Univ, Dept Nutr & Hlth, Key Lab Precis Nutr & Food Qual, Beijing 100193, Peoples R China.

通讯机构：

[Zhang, L ; Liu, JY ] C

Chinese Acad Med Sci 2019RU014, China Natl Ctr Food Safety Risk Assessment CFSA, Res Unit Food Safety, NHC Key Lab Food Safety Risk Assessment, Beijing 100021, Peoples R China.

China Agr Univ, Dept Nutr & Hlth, Key Lab Precis Nutr & Food Qual, Beijing 100193, Peoples R China.

语种：

英文

关键词：

6:2 Cl-PFESA;PFOS;benchmark dose;newborns;thyroid disruption

期刊：

Environmental Science & Technology

ISSN：

0013-936X

年：

2023

卷：

期：

页码：

11489-11498

DOI：

10.1021/acs.est.3c03952

基金类别：

National Natural Science Foundation of China [21976046]; National Institute of Environmental Health Sciences (NIEHS) of the National Institutes of Health (NIH) [R01ES025796]

机构署名：

本校为第一机构

院系归属：

食品科学与工程学院

摘要：

Growing toxicologic evidence suggests that emerging perfluoroalkylsubstances (PFASs), like chlorinated polyfluoroalkyl ether sulfonate(Cl-PFESA), may be as toxic or more toxic than perfluorooctanesulfonate(PFOS) and perfluorooctanoic acid (PFOA). However, further investigationsare needed in terms of the human health risk assessment. This studyexamined the effects of emerging and legacy PFAS exposure on newbornthyroid homeostasis and compared the thyroid disruption caused by6:2 Cl-PFESA and PFOS using a benchmark dose approach. The healtheffects of mixture and individual exposure were estimated...

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6:2 Chlorinated Polyfluoroalkyl Ether Sulfonates Exert Stronger Thyroid Homeostasis Disruptive Effects in Newborns than Perfluorooctanesulfonate: Evidence Based on Bayesian Benchmark Dose Values from a Population Study

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