Studies on mechanism of free Nε-(carboxymethyl)lysine-induced toxic injury in mice

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成果类型：

期刊论文

作者：

Wang, Yi-Xin;Xu, Hao;Liu, Xin;Liu, Liang;Wu, Yong-Ning;...

通讯作者：

Gong, Zhi-Yong

作者机构：

[Wang, Yi-Xin; Xu, Hao; Liu, Liang; Gong, Zhi-Yong; Liu, Xin] Wuhan Polytech Univ, Coll Food Sci & Engn, Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan, Hubei, Peoples R China.

[Wu, Yong-Ning] Minist Hlth, China Natl Ctr Food Safety Risk Assessment, Key Lab Food Safety Risk Assessment, Beijing, Peoples R China.

[Gong, Zhi-Yong] Wuhan Polytech Univ, Coll Food Sci & Engn, 68 XueFuNan Rd, Wuhan 430023, Hubei, Peoples R China.

通讯机构：

[Gong, Zhi-Yong] W

Wuhan Polytech Univ, Coll Food Sci & Engn, 68 XueFuNan Rd, Wuhan 430023, Hubei, Peoples R China.

语种：

英文

关键词：

advanced glycation end product receptor;lysine derivative;messenger RNA;n epsilon(carboxymethyl)lysine;transforming growth factor beta;tumor necrosis factor;unclassified drug;vascular cell adhesion molecule 1;advanced glycation end product receptor;Ager protein, mouse;lysine;N(6)-carboxymethyllysine;transforming growth factor beta;tumor necrosis factor;vascular cell adhesion molecule 1;animal experiment;animal tissue;Article;controlled study;drug intoxication;female;immunohistochemistry;kidney injury;kidney tissue;liver injury;liver tissue;male;mouse;mRNA expression level;nonhuman;oxidative stress;real time polymerase chain reaction;Western blotting;analogs and derivatives;animal;chemically induced;drug effect;inflammation;kidney;liver;metabolism;pathology;Animals;Female;Inflammation;Kidney;Liver;Lysine;Male;Mice;Oxidative Stress;Receptor for Advanced Glycation End Products;Transforming Growth Factor beta;Tumor Necrosis Factor-alpha;Vascular Cell Adhesion Molecule-1

期刊：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

ISSN：

1095-6670

年：

2019

卷：

期：

页码：

e22322

DOI：

10.1002/jbt.22322

基金类别：

We thank for technical assistance provided by the teachers of College of Food Science and Engineering, Wuhan Polytechnic University. This study was supported by the National Key Research and Development Program of China (2017YFC1600500). National Key Research and Development Program of China, Grant/Award Number: 2017YFC1600500

机构署名：

本校为第一且通讯机构

院系归属：

食品科学与工程学院

摘要：

Nε-(carboxymethyl)lysine (CML), which is a compound produced when food is processed, has aroused concern in recent years because of its potentially dangerous effects. This study aimed to investigate the mechanism of free CML-induced toxic injury in mice. The inflammatory cytokine tumor necrosis factor-α, transforming growth factor-β, vascular cell adhesion molecule-1 mRNA expression levels of CML-infected mice liver and kidney tissues significantly increased. While CML receptor—receptor for advanced glycation end products (RAGE) protein exp...

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