期刊论文

Zhang, Xiao-Dong

英文

Scientific Reports

2045-2322

2014

4

1

6910-

10.1038/srep06910

National Basic Research Program of ChinaNational Basic Research Program of China [2011CB944404]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270306]; National Science and Technology Support Project [2014BAI02B01, 2012BAI39B02, 2012BAI39B03]; Trans-Century Training Programme Foundation for the Talents by the State Education Commission [NCET-10-0655]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [204275771]

本校为其他机构

Cyclins are essential for cell proliferation, the cell cycle and tumorigenesis in all eukaryotes. UbcH10 regulates the degradation of cyclins in a ubiquitin-dependent manner. Here, we report that UbcH10 is likely involved in tumorigenesis. We found that cancer cells exposed to n-acetyl-leu-leu-norleucinal (ALLN) treatment and UbcH10 depletion exhibit a synergistic therapeutic effect. Abundant expression of UbcH10 drives resistance to ALLN-induced cell death, while cells deficient in UbcH10 were susceptible to ALLN-induced cell death. The depletion of UbcH10 hindered tumorigenesis both in vitro...