Clinical value of thalidomide on kk-rat model through TNF-a mediated inflammation approach

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成果类型：

期刊论文

作者：

Huang, Min;Duan, Jie;Yu, Bin;Zheng, Si-lin;Chen, Qi;...

通讯作者：

Yu, B.

作者机构：

[Huang, Min] Southwest Med Univ, Affiliated Hosp, Dept Resp & Crit Care Med, Luzhou, Peoples R China.

[Zheng, Si-lin; Chen, Qi; Huang, Min] Southwest Med Univ, Affiliated Hosp, Nuring Dept, Luzhou, Peoples R China.

[Duan, Jie] Pidu Dist Peoples Hosp, Chengdu Med Coll, Affiliated Hosp 3, Dept Pharm, Chengdu, Peoples R China.

[Yu, Bin] Mianyang Cent Hosp, Dept Pharm, Mianyang, Sichuan, Peoples R China.

[Lin, Fei] Chengdu Med Coll, Clin Med Coll, Dept Pharm, Chengdu, Peoples R China.

通讯机构：

Department of Pharmacy, Mianyang Central Hospital, Mianyang, China

语种：

英文

关键词：

thalidomide;tucorrelation mor necrosis factor -alpha;interleukin-1 beta;kidney tubules epithelial cell

期刊：

Food Science and Technology

ISSN：

0101-2061

年：

2022

卷：

DOI：

10.1590/fst.06821

基金类别：

Scientific Research Subject of Health Commission of Sichuan Province [18PJ540]; Hypertension Disease (Taige) Special Scientific Research Project of Sichuan Medical Association [2019TG28]

机构署名：

本校为其他机构

摘要：

To observe the influence of thalidomide on tumor necrosis factor-a (TNF-α) of spontaneous type-2 diabetes rat (kk-Ay rat) model, and to explore the clinical value of TNF-a mediated inflammation approach to improve the injury on epithelial cell of kidney tubules. There are 30 kk-Ay rates being chosen to establish the Diabetic Nephropathy model and divided into thalidomide group and the model control group, 15 pieces for each group respectively. The levels of TNF-α, IL-1β, interleukin-6 (IL-6) and interleukin-18 (IL-18) of kk-Ay in the thalido...

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Clinical value of thalidomide on kk-rat model through TNF-a mediated inflammation approach

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