期刊论文

Liu, Yulan

英文

Journal of Functional Foods

1756-4646

2018

46

482-489

10.1016/j.jff.2018.05.015

This work was supported by the Project of the Hubei Provincial Department of Education [grant number T201508]; the National Natural Science Foundation of China [grant number 31772615]; and the State's Key Project of Research and Development Plan [grant number 2016YFD0501210]. This work was supported by the Project of the Hubei Provincial Department of Education [grant number T201508 ]; the National Natural Science Foundation of China [grant number 31772615 ]; and the State's Key Project of Research and Development Plan [grant number 2016YFD0501210 ].

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The hepatoprotective effects of flaxseed oil (FO) were tested in a pig model of lipopolysaccharide (LPS)-induced liver injury. Twenty-four piglets were used in a 2 × 2 factorial design including diet and an LPS challenge. After 3 weeks of feeding with 5% FO or 5% corn oil, pigs were challenged with LPS or saline. FO alleviated LPS-induced morphological liver damage, reduced serum alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activities, and increased claudin-1 protein expression. FO decreased tumor necrosis fact...