Pregnancy Induces an Immunological Memory Characterized by Maternal Immune Alterations Through Specific Genes Methylation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Xiaobo;Wang, Liling;Zhao, Sijia;Liu, Hong;Chen, Si;...

通讯作者：

Liao, A.;Yin, Z.;Mor, G.

作者机构：

[Zhao, Sijia; Huang, Xiaobo; Wang, Liling; Liao, Aihua; Liu, Hong; Mor, Gil] Huazhong Univ Sci & Technol, Tongji Med Coll, Ctr Reprod Med, Inst Reprod Hlth, Wuhan, Peoples R China.

[Chen, Si] Wuhan Polytech Univ, Hubei Prov Engn Res Ctr Hlth Food, Sch Biol & Pharmaceut Engn, Wuhan, Peoples R China.

[Wu, Li] Anhui Med Univ, Anhui Prov Hosp, Dept Obstet & Gynecol, Ctr Reprod Med, Hefei, Peoples R China.

[Liu, Liping] Wuhan Women & Children Med Care Ctr, Wuhan, Peoples R China.

[Maxwell, Anthony; Ding, Jiahui; Mor, Gil] Wayne State Univ, Sch Med, CS Mott Ctr Human Growth & Dev, Detroit, MI 48202 USA.

通讯机构：

[Mor, G.; Liao, A.] I

[Yin, Z.] Z

Zhuhai Institute of Translational Medicine, China

Institute of Reproductive Health, China

语种：

英文

关键词：

Pregnancy;Immunological memory;epigenetic;Preeclampsia;immune cells

期刊：

FRONTIERS IN IMMUNOLOGY

ISSN：

1664-3224

年：

2021

卷：

页码：

686676

DOI：

10.3389/fimmu.2021.686676

基金类别：

The study was supported by National Key Research & Developmental Program of China (2018YFC1003900; 2018YFC1003904); NIAID (1R01AI145829-01).

机构署名：

本校为其他机构

院系归属：

生命科学与技术学院

摘要：

During pregnancy, the maternal immune system undergoes major adaptive modifications that are necessary for the acceptance and protection of the fetus. It has been postulated that these modifications are temporary and limited to the time of pregnancy. Growing evidence suggests that pregnancy has a long-term impact on maternal health, especially among women with pregnancy complications, such as preeclampsia (PE). In addition, the presence of multiple immunological-associated changes in women that remain long after delivery has been reported. To e...

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Pregnancy Induces an Immunological Memory Characterized by Maternal Immune Alterations Through Specific Genes Methylation

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