Identification of the hub genes and transcription factor-miRNA axes involved in Helicobacter pylori-associated gastric cancer

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成果类型：

期刊论文

作者：

Zhao, Peng;Ma, Xianxiong;Cheng, Jiancheng;Chen, Hengyu;Li, Lei

通讯作者：

Chen, HY;Li, L

作者机构：

[Zhao, Peng] Huazhong Univ Sci & Technol, Dept Hepatobiliary Surg, Wuhan, Hubei, Peoples R China.

[Ma, Xianxiong] Huazhong Univ Sci & Technol, Dept Gastrointestinal Surg, Union Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China.

[Cheng, Jiancheng] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiovasc Surg, Wuhan 430022, Hubei, Peoples R China.

[Chen, Hengyu] Hainan Med Univ, Dept Breast & Thyroid Surg, Affiliated Hosp 2, 368 Yehai Ave, Haikou 570100, Hainan, Peoples R China.

[Chen, Hengyu] Union Hosp, Tongji Med Coll, Dept Pancreat Surg, Wuhan, Peoples R China.

通讯机构：

[Chen, HY ; Li, L ] H

Hainan Med Univ, Dept Breast & Thyroid Surg, Affiliated Hosp 2, 368 Yehai Ave, Haikou 570100, Hainan, Peoples R China.

Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Breast & Thyroid Surg, 1277 Jiefang Ave, Wuhan 430022, Hubei, Peoples R China.

语种：

英文

关键词：

Helicobacter pylori;The Cancer Genome Atlas;bioinformatics;gastric cancer;microRNA;transcription factor

期刊：

Oncology Letters

ISSN：

1792-1074

年：

2022

卷：

期：

页码：

DOI：

10.3892/ol.2022.13209

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81702397]; Hainan Province Clinical Medical Center

机构署名：

本校为其他机构

摘要：

It has been previously reported that transcription factor-microRNA (TF-miRNA) axes play a significant role in the carcinogenesis of several types of malignant tumor. However, there is a lack of research into the differences in the mechanism of Helicobacter pylori (HP)-positive [HP(+)] and HP-negative [HP(-)] gastric cancer. The aim of the present study was to identify the hub genes and TF-miRNA axes, and to determine the potential mechanisms involved in HP-associated gastric cancer. HP-associated mRNA and miRNA data, as well as the correspondin...

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Identification of the hub genes and transcription factor-miRNA axes involved in Helicobacter pylori-associated gastric cancer

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