Zaltoprofen and its novel analogues exhibit dual targeting of COX-2 and PPAR-γ, providing a strategy to alleviate lipopolysaccharide – induced acute lung injury - 成果

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Zaltoprofen and its novel analogues exhibit dual targeting of COX-2 and PPAR-γ, providing a strategy to alleviate lipopolysaccharide – induced acute lung injury

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Lu, Qirong;Zhao, Yongxia;Xu, Xiaoqing;Guo, Pu;Ares, Irma;...

通讯作者：

Anadón, Arturo;Pan, Yuanhu;Wang, Xu

作者机构：

[Guo, Pu; Lu, Qirong] Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China

[Xu, Xiaoqing; Wang, Xu; Zhao, Yongxia; Pan, Yuanhu] National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China

[Guo, Pu] National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China

[Lopez-Torres, Bernardo; Martínez, Marta; Martínez-Larrañaga, María-Rosa; Martínez, María-Aránzazu; Ares, Irma] Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid 28040, Spain

[Anadón, Arturo] Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid 28040, Spain. Electronic address: aanadon@ucm.es

通讯机构：

[Anadón, Arturo] D

[Wang, Xu; Pan, Yuanhu] M

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid, Madrid 28040, Spain. Electronic address:

MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Hubei 430070, China. Electronic address:

语种：

英文

关键词：

Acute lung injury;Cyclooxygenase-2;Dual target;Peroxisome proliferator-activated receptor-γ;Strategy;Zaltoprofen

期刊：

Biochemical Pharmacology

ISSN：

0006-2952

年：

2025

卷：

242

期：

Pt 4

页码：

117420

DOI：

10.1016/j.bcp.2025.117420

机构署名：

本校为第一机构

院系归属：

动物科学与营养工程学院

摘要：

Acute lung injury (ALI) is a multi-system and multifactorial disease, which is characterised by an uncontrolled inflammatory response and high mortality. Zaltoprofen (ZPF), is a non-steroidal anti-inflammatory drug (NSAID) with powerful anti-inflammatory effects, as well as an analgesic action on inflammatory pain. Therefore, this research study aims to explore whether ZPF, its main metabolite M2 (S-oxide-zaltoprofen) and novel analogues can alleviate ALI through multiple targets. Based on molecular docking, the similar topological structure bi...

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Zaltoprofen and its novel analogues exhibit dual targeting of COX-2 and PPAR-γ, providing a strategy to alleviate lipopolysaccharide – induced acute lung injury

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