Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria

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成果类型：

期刊论文

作者：

Speck, Sarah L.;Bhatt, Dhaval P.;Zhang, Qiang;Adak, Sangeeta;Yin, Li;...

通讯作者：

Wei, Xiaochao;Semenkovich, CF

作者机构：

[Zhang, Wei; Zhang, Qiang; Wei, Xiaochao; Semenkovich, Clay F.; Dong, Guifang; Adak, Sangeeta; Yin, Li; Speck, Sarah L.; Feng, Chu] Washington Univ, Div Endocrinol Metab & Lipid Res, St Louis, MO 63110 USA.

[Bhatt, Dhaval P.; Semenkovich, Clay F.; Major, M. Ben] Washington Univ, Dept Cell Biol & Physiol, St Louis, MO 63110 USA.

[Dong, Guifang] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Major, M. Ben] Washington Univ, Dept Otolaryngol, St Louis, MO 63110 USA.

通讯机构：

[Wei, XC; Semenkovich, CF ] W

Washington Univ, Div Endocrinol Metab & Lipid Res, St Louis, MO 63110 USA.

Washington Univ, Dept Cell Biol & Physiol, St Louis, MO 63110 USA.

语种：

英文

关键词：

CP: Metabolism;acyl-protein thioesterase 1;acyl-protein thioesterase 2;gluconeogenesis;glutamine;insulin;liver;palmitoylation;proximity labeling

期刊：

Cell Reports

ISSN：

2211-1247

年：

2023

卷：

期：

页码：

113389

DOI：

10.1016/j.celrep.2023.113389

基金类别：

WU Institute of Clinical and Translational Sciences [NCATS UL1 TR000448]; Siteman Comprehensive Cancer Center Support Grant [T32 GM007200]; NIH Medical Scientist Training Program [F30 DK131830, R01 HL157154, P30 DK020579, NIGMS P41 GM103422]; Mass Spectrometry Research Resource; [NCI P30 CA091842]

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

Acyl-protein thioesterases 1 and 2 (APT1 and APT2) reverse S-acylation, a potential regulator of systemic glucose metabolism in mammals. Palmitoylation proteomics in liver-specific knockout mice shows that APT1 predominates over APT2, primarily depalmitoylating mitochondrial proteins, including proteins linked to glutamine metabolism. miniTurbo-facilitated determination of the protein-protein proximity network of APT1 and APT2 in HepG2 cells reveals APT proximity networks encompassing mitochondrial proteins including the major translocases Tomm20 and Timm44. APT1 also interacts with Slc1a5 (AS...

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Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria

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