期刊论文

Zhuo, MQ

英文

Fish Physiology and Biochemistry

0920-1742

2022

48

3

571-583

10.1007/s10695-022-01071-7

This work was supported by the National Natural Science Foundation of China (Grant No. 31902381).

本校为第一且通讯机构

In this study, the transcriptional regulation of PI3KC3 by three transcription factors (PPARγ, PPARα, and STAT3) and the potential role of PI3KC3 in mediating lipid accumulation were determined in yellow catfish Pelteobagrus fulvidraco. The 5’-deletion assay, overexpression assay, site-mutation assay, and electrophoretic mobility shift assay suggested that PPARα, PPARγ, and STAT3 negatively regulated the promoter activity of pi3kc3. Moreover, the transcriptional inactivation of pi3kc3 was directly mediated by PPARα and PPARγ under fatty ...