Differential impact of the triple helix dissociation degree of collagen on the binding efficiency with cancer cells and normal cells

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成果类型：

期刊论文

作者：

Kang, Delai;Li, Ke;Zuo, Long;Wu, Hui;Huang, Siying;...

通讯作者：

Xu, CZ;Wang, HB

作者机构：

[Kang, Delai; Xu, Chengzhi; Wei, Benmei; Huang, Siying; Li, Ke; Wu, Hui; Zuo, Long; Xu, CZ; Zhang, Juntao] Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan, Hubei, Peoples R China.

[Wang, Haibo] Hubei Engn Univ, Coll Life Sci & Technol, Hubei Key Lab Qual Control Characterist Fruits & V, Xiaogan, Hubei, Peoples R China.

通讯机构：

[Xu, CZ ] W

[Wang, HB ] H

Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan, Hubei, Peoples R China.

Hubei Engn Univ, Coll Life Sci & Technol, Hubei Key Lab Qual Control Characterist Fruits & V, Xiaogan, Hubei, Peoples R China.

语种：

英文

关键词：

Cancer cells;Cell adhesion;Diseases;Dissociation;Efficiency;Endothelial cells;Mammals;Binding efficiency;Bovine tendon collagens;Cancer cells;Cancer development;Cell capture;Cell-adhesion assays;Dissociation degree;Fluorescence labelling;Impact of changes;Triple helixes;Collagen;collagen;fluorescent dye;Article;bovine;cancer cell;cancer incidence;cell adhesion;cell adhesion assay;cell count;chemical bond;circular dichroism;coculture;controlled study;correlation analysis;dissociation;enthalpy;environmental temperature;heat treatment;human;human cell;hydrogen bond;nonhuman;tendon;triple helix

期刊：

NEW JOURNAL OF CHEMISTRY

ISSN：

1144-0546

年：

2024

卷：

期：

页码：

7990-7996

DOI：

10.1039/d4nj00109e

基金类别：

The authors would like to thank all the reviewers who participated in the review. This research was supported by the National Natural Science Foundation of China (No. 22178277 and 22378320) and the Knowledge Innovation Program of Wuhan-Basi Research (No. 2023020201010148).

机构署名：

本校为第一且通讯机构

院系归属：

化学与环境工程学院

摘要：

Collagen plays a crucial role in cancer development and migration. However, the impact of changes in the collagen molecular structure on its interaction with cancer cells remains unclear. In this study, natural bovine tendon collagen was heat-treated to obtain collagen samples with different triple helix dissociation degrees. Three methods, including cell adhesion assay, fluorescence labeling assay, and cancer cell capture assay, were employed to compare the binding efficiency of collagen samples to both breast cancer cells (MCF-7) and human um...

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Differential impact of the triple helix dissociation degree of collagen on the binding efficiency with cancer cells and normal cells

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