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Co-occurrence of Mycotoxin-Induced Hepatotoxicity in Mice Inhibited by Lycopene: Mitochondrial Impairment and Early Hepatic Fibrosis

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成果类型:
期刊论文
作者:
Lin, Jia;Liang, Tianzeng;Huang, Yang;Zuo, Cuige;Wang, Dan;...
通讯作者:
Liu, YL
作者机构:
[Liang, Tianzeng; Zuo, Cuige; Liu, Yulan; Huang, Yang; Lin, Jia; Wang, Dan; Liu, YL] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Safe, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.
通讯机构:
[Liu, YL ] W
Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Safe, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.
语种:
英文
关键词:
aflatoxin B1;deoxynivalenol;hepatic fibrosis;lycopene;mitochondrial impairment;zearalenone
期刊:
MOLECULAR NUTRITION & FOOD RESEARCH
ISSN:
1613-4125
年:
2023
卷:
67
期:
19
页码:
e2200671
基金类别:
National Natural Science Foundation of China [32002346]; Wuhan Science and Technology Bureau [2022020801010391]
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
Lycopene ameliorates early hepatic fibrosis induced by co‐exposure to zearalenone, deoxynivalenol, and aflatoxin B1 via inhibiting suppression of CYP2E1‐mediated oxidative injury and mitochondrial damage. Scope Mycotoxins co‐contamination of agricultural products poses a serious threat to human and animal health, especially hepatic dysfunction. Zearalenone (ZEN), deoxynivalenol (DON), and aflatoxin B1 (AFB1) are three commonly co‐occurring mycotoxins. This study is to determine whether lycopene (LYC) can alleviate hepatic toxicity induced b...

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