USP49 participates in the DNA damage response by forming a positive feedback loop with p53 article

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tu, Rongfu;Kang, Wenqian;Yang, Xuefei;Zhang, Qi;Xie, Xiaoyu;...

通讯作者：

Du, Run-Lei;Wang, Hui

作者机构：

[Yang, Xuefei; Tu, Rongfu; Zhang, Qi; Xie, Xiaoyu; Kang, Wenqian; Zhang, Xiao-Dong; Du, Run-Lei] Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072, Hubei, Peoples R China.

[Liu, Wenbin] Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan 430023, Hubei, Peoples R China.

[Zhang, Jinxiang] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Emergency Surg, Wuhan 430022, Hubei, Peoples R China.

[Wang, Hui] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Vasc Surg, Wuhan 430030, Hubei, Peoples R China.

通讯机构：

[Du, Run-Lei] W

[Wang, Hui] H

Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072, Hubei, Peoples R China.

Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Vasc Surg, Wuhan 430030, Hubei, Peoples R China.

语种：

英文

期刊：

CELL DEATH & DISEASE

ISSN：

2041-4889

年：

2018

卷：

期：

页码：

553

DOI：

10.1038/s41419-018-0475-3

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270306, 31501148, 81470375, 81670575]; National Science and Technology Support Project [2014BAI02B00]

机构署名：

本校为其他机构

院系归属：

医学与健康学院

摘要：

The p53 tumor suppressor is a critical factor in the DNA damage response (DDR), and regulation of p53 stability has a key role in this process. In our study, we identified USP49 as a novel deubiquitinase (DUB) for p53 from a library consisting of 80 DUBs and found that USP49 has a positive effect on p53 transcriptional activity and protein stability. Investigation of the mechanism revealed that USP49 interacts with the N terminus of p53 and suppresses several types of p53 ubiquitination. Furthermore, USP49 rendered HCT116 cells more sensitive t...

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USP49 participates in the DNA damage response by forming a positive feedback loop with p53 article

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