USP49 participates in the DNA damage response by forming a positive feedback loop with p53

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tu, Rongfu;Kang, Wenqian;Yang, Xuefei;Zhang, Qi;Xie, Xiaoyu;...

通讯作者：

Du, Run-Lei;Wang, Hui

作者机构：

[Yang, Xuefei; Tu, Rongfu; Zhang, Qi; Xie, Xiaoyu; Kang, Wenqian; Zhang, Xiao-Dong; Du, Run-Lei] Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072, Hubei, Peoples R China.

[Liu, Wenbin] Wuhan Polytech Univ, Coll Hlth Sci & Nursing, Wuhan 430023, Hubei, Peoples R China.

[Zhang, Jinxiang] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Emergency Surg, Wuhan 430022, Hubei, Peoples R China.

[Wang, Hui] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Vasc Surg, Wuhan 430030, Hubei, Peoples R China.

通讯机构：

[Du, Run-Lei] W

[Wang, Hui] H

Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan 430072, Hubei, Peoples R China.

Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Vasc Surg, Wuhan 430030, Hubei, Peoples R China.

语种：

英文

期刊：

CELL DEATH & DISEASE

ISSN：

2041-4889

年：

2018

卷：

期：

页码：

1-11

DOI：

10.1038/s41419-018-0475-3

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270306, 31501148, 81470375, 81670575]; National Science and Technology Support Project [2014BAI02B00]

机构署名：

本校为其他机构

院系归属：

医学与健康学院

摘要：

AbstractThe p53 tumor suppressor is a critical factor in the DNA damage response (DDR), and regulation of p53 stability has a key role in this process. In our study, we identified USP49 as a novel deubiquitinase (DUB) for p53 from a library consisting of 80 DUBs and found that USP49 has a positive effect on p53 transcriptional activity and protein stability. Investigation of the mechanism revealed that USP49 interacts with the N terminus of p53 and suppresses several types of p53 ubiquitination. Furthermore, USP49 rendered HCT116 cells more sensitive to etoposide (Eto)-induced DNA damage and w...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

USP49 participates in the DNA damage response by forming a positive feedback loop with p53

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问