Baicalin, Amoxicillin, and Probenecid Provide Protection in Mice Against Glaesserella parasuis Challenge

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Jingyang;Luo, Ronghui;Fu, Yunjian;Liu, Siyu;Dong, Qiaoli;...

通讯作者：

Fu, Shulin;Qiu, YS

作者机构：

[Dong, Qiaoli; Fu, Shulin; Zhu, Yi; Qiu, Yinsheng; Luo, Ronghui; Fu, Yunjian; Ye, Chun; Lu, Qirong; Sun, Yamin; Tian, Xinyue; Liu, Siyu; Li, Jingyang; Wang, Peiyi; Guo, Ling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Dong, Qiaoli; Fu, Shulin; Zhu, Yi; Qiu, Yinsheng; Luo, Ronghui; Fu, Yunjian; Ye, Chun; Lu, Qirong; Sun, Yamin; Tian, Xinyue; Liu, Siyu; Li, Jingyang; Wang, Peiyi; Guo, Ling] Hubei Collaborat Innovat Ctr Anim Nutr & Feed Safe, Wuhan 430023, Peoples R China.

通讯机构：

[Fu, SL; Qiu, YS ] W

Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

Hubei Collaborat Innovat Ctr Anim Nutr & Feed Safe, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Glaesserella parasuis;amoxicillin;anti-inflammatory;antibacterial;baicalin;probenecid

期刊：

Biomolecules

ISSN：

2218-273X

年：

2025

卷：

期：

DOI：

10.3390/biom15040507

基金类别：

National Natural Science Foundation of China; Key Research and Development Plan of Hubei Province, China [2023BBB069]; [32072917]; [32273067]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Glaesserella parasuis (G. parasuis) causes Glässer's disease and systemic inflammatory responses in the host. The currently available therapies have limited efficacy and fail to achieve a balance between anti-inflammatory and antibacterial effects. In this study, we investigated the effects of baicalin, amoxicillin, and probenecid on blood biochemical parameters, routine blood indicators, survival rate, bacterial burden, and pathological tissue damage in G. parasuis-challenged mice. Treatment with baicalin, amoxicillin, and probenecid signific...

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Baicalin, Amoxicillin, and Probenecid Provide Protection in Mice Against Glaesserella parasuis Challenge

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