A type 2 immune circuit and arachidonic acid metabolism role in anti-nematode infection: evidence from transcriptome and targeted metabolome data in goat

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成果类型：

期刊论文

作者：

Chen, W. X.;Yan, Q. X.;Zhong, R. Z.;Tang, S. X.;Loor, J. J.;...

通讯作者：

Yan, QX

作者机构：

[Yan, Q. X.; Tang, S. X.; Chen, W. X.; Tan, Z. L.; Yan, QX] Chinese Acad Sci, Inst Subtrop Agr, CAS Key Lab Agroecol Proc Subtrop Reg, Natl Engn Lab Pollut Control & Waste Utilizat Live, Changsha 410125, Hunan, Peoples R China.

[Chen, W. X.] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Zhong, R. Z.] Chinese Acad Sci, Northeast Inst Geog & Agroecol, Jilin Prov Key Lab Grassland Farming, Changchun 130102, Jilin, Peoples R China.

[Loor, J. J.] Univ Illinois, Dept Anim Sci, Div Nutr Sci, Urbana, IL 61801 USA.

通讯机构：

[Yan, QX ] C

Chinese Acad Sci, Inst Subtrop Agr, CAS Key Lab Agroecol Proc Subtrop Reg, Natl Engn Lab Pollut Control & Waste Utilizat Live, Changsha 410125, Hunan, Peoples R China.

语种：

英文

关键词：

Abomasal bacteria;Abomasum transcriptome;Arachidonic acid metabolites;Haemonchus contortus;Type 2 cytokines

期刊：

ANIMAL

ISSN：

1751-7311

年：

2024

卷：

期：

页码：

101338

DOI：

10.1016/j.animal.2024.101338

基金类别：

International Part-nership Program of the Chinese Academy of Sciences [092GJHZ2023050FN]; National Natural Science Foundation of China [31730092]; Natural Science Foundation of Changsha city [kq2208245]

机构署名：

本校为其他机构

院系归属：

动物科学与营养工程学院

摘要：

The gastrointestinal nematode infection poses a covert threat to both humans and domestic animals worldwide, eliciting a type 2 immune response within the small intestine. Intestinal tuft cells detect the nematode and activated group 2 innate lymphoid cells. Tuft cell-derived leukotrienes (one of the metabolites of arachidonic acid) were found to drive rapid anti-helminth immunity, but it is still poorly understood whether the tuft cell-mediated type 2 immune circuit and arachidonic acid metabolism modulate anti-parasitic immunity in the gastric epithelium. This study was designed to evaluate ...

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A type 2 immune circuit and arachidonic acid metabolism role in anti-nematode infection: evidence from transcriptome and targeted metabolome data in goat

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