期刊论文

Yu, Xiaoli;Zhang, Shulin

英文

Cellular Immunology

0008-8749

2019

335

85-92

10.1016/j.cellimm.2018.11.007

Financial support from the National Science and Technology Major Project (No. 2017ZX10201301-003-001, No. 2017ZX10201301-003-003), the National Natural Science Foundation of China (No. 81871613, No. 81501715) and Shanghai Jiao Tong University School of Medicine Technology Transfer Project (No. ZT201720) are gratefully acknowledged.

本校为第一且通讯机构

Lipoarabinomannan (LAM) is an important virulent factor secreted by mycobacteria, which generally elicit a strong immune response in the host. In this study, the structural difference of LAMs from three mycobacterial strains, Mycobacterium tuberculosis H37Rv, Mycobacterium smegmatis mc(2)155 and a newly discovered clinical isolate, M. sp. QGD101, was analyzed and further evaluated whether these LAMs can induce DC maturation and promote the immunomodulatory properties. The results reveal that the major structural difference of these LAMs is the amount of mannosyl residues, especially at the ter...