Metal-amplified sonodynamic therapy of Ti-based chitosan-polyvinyl alcohol hybrid hydrogel dressing against subcutaneous Staphylococcus aureus infection

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成果类型：

期刊论文

作者：

Li, Shu-Lan*;Dong, Hong -Li;Hou, Hua-Ying;Chu, Xu;Chen, Hongli;...

通讯作者：

Li, Shu-Lan;Liu, Y

作者机构：

[Sun, Yue; Dong, Hong -Li; Liu, Yi; Li, Shu-Lan] Tiangong Univ, Sch Chem Engn & Technol, State Key Lab Separat Membranes & Membrane Proc, Tianjin 300387, Peoples R China.

[Sun, Yue; Dong, Hong -Li; Li, Shu-Lan; Liu, Yi] Tiangong Univ, Sch Chem, State Key Lab Separat Membranes & Membrane Proc, Tianjin 300387, Peoples R China.

[Hou, Hua-Ying; Chu, Xu] Tiangong Univ, Sch Elect & Informat Engn, Tianjin 300387, Peoples R China.

[Hou, Hua-Ying; Chu, Xu] Tiangong Univ, Sch Mat Engn & Technol, Tianjin 300387, Peoples R China.

[Chen, Hongli] Tiangong Univ, Sch Life Sci, Tianjin 300387, Peoples R China.

通讯机构：

[Li, SL; Liu, Y ] T

Tiangong Univ, Sch Chem, State Key Lab Separat Membranes & Membrane Proc, Tianjin 300387, Peoples R China.

Wuhan Polytech Univ, Sch Chem & Environm Engn, Wuhan 430023, Peoples R China.

语种：

英文

关键词：

Antibacterial sonodynamic therapy;Hybrid hydrogel;Wound healing

期刊：

International Journal of Biological Macromolecules

ISSN：

0141-8130

年：

2024

卷：

258

期：

Pt 2

页码：

129120

DOI：

10.1016/j.ijbiomac.2023.129120

基金类别：

National Natural Science Foundation of China [22203061]; Natural Science Foundation of Tianjin [21JCQNJC01470, 22JCYBJC01130]; Science and Technology Plans of Tianjin [22ZYJDSS00070]

机构署名：

本校为通讯机构

院系归属：

化学与环境工程学院

摘要：

Ultrasound (US)-mediated sonodynamic therapy (SDT) has received extensive attention in pathogen elimination for non-invasiveness and high spatial and temporal accuracy. Considering that hydrogel can provide a healing-friendly environment for wounds, in this work, hybrid hydrogels are constructed by embedding Ag doped TiO(2) nanoparticles in chitosan-polyvinyl alcohol hydrogels for enhanced sonodynamic antibacterial therapy. With metal silver doped, TiO(2) nanoparticles sonosensitivity is improved to generate more reactive oxygen species (ROS), which endows hybrid hydrogels with high-efficient ...

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Metal-amplified sonodynamic therapy of Ti-based chitosan-polyvinyl alcohol hybrid hydrogel dressing against subcutaneous Staphylococcus aureus infection

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