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Quercetin Ameliorates Deoxynivalenol-Induced Intestinal Injury and Barrier Dysfunction Associated with Inhibiting Necroptosis Signaling Pathway in Weaned Pigs

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成果类型:
期刊论文
作者:
Liu, Jiahao;Zhou, Mohan;Xu, Qilong;Lv, Qingqing;Guo, Junjie;...
通讯作者:
Xiao, Kan;Liu, YL
作者机构:
[Liu, Jiahao; Liu, Yulan; Xiao, Kan; Guo, Junjie; Liu, YL; Qin, Xu; Chen, Shaokui; Xu, Qilong; Lv, Qingqing; Zhou, Mohan; Xu, Xiaoye] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.
[Zhao, Jiangchao] Univ Arkansas, Dept Anim Sci, Div Agr, Fayetteville, AR 72701 USA.
通讯机构:
[Xiao, K; Liu, YL ] W
Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.
语种:
英文
关键词:
Quercetin;deoxynivalenol;intestinal injury;barrier dysfunction;necroptosis signaling pathway
期刊:
International Journal of Molecular Sciences
ISSN:
1661-6596
年:
2023
卷:
24
期:
20
页码:
15172-
基金类别:
This research was funded by the National Natural Science Foundation of China (32272906 and U22A20517) and Wuhan Science and Technology Bureau (2022020801010391).
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
Quercetin (Que) is a flavonol compound found in plants, which has a variety of biological activities. Necroptosis, a special form of programmed cell death, plays a vital role in the development of many gastrointestinal diseases. This study aimed to explore whether Que could attenuate the intestinal injury and barrier dysfunction of piglets after deoxynivalenol (DON) exposure through modulating the necroptosis signaling pathway. Firstly, twenty-four weaned piglets were used in a 2 × 2 factorial design and the main factors, including Que (basal ...

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