Using network pharmacology and molecular docking to uncover the mechanism by which quercetin alleviates deoxynivalenol-induced porcine intestinal injury.

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成果类型：

期刊论文

作者：

Guo, Pu;Li, Xuemin;Xue, Yunda;Lu, Qirong;Liu, Yu;...

通讯作者：

Wang, Xu;Qiu, Yinsheng

作者机构：

[Liu, Yu; Xue, Yunda; Xiong, Jianglin; Guo, Pu; Ye, Chun; Wu, Zhongyuan; Fu, Shulin; Lu, Qirong; Li, Xuemin] Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, 430023, China

[Wang, Xu] National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, 430070, China. Electronic address: wangxu@mail.hzau.edu.cn

[Qiu, Yinsheng] Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, 430023, China. Electronic address: qiuyinsheng6405@whpu.edu.cn

通讯机构：

[Wang, Xu] N

[Qiu, Yinsheng] H

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, 430070, China. Electronic address:

Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, 430023, China. Electronic address:

语种：

英文

关键词：

Deoxynivalenol;Molecular docking;Network pharmacology;Porcine intestinal injury;Quercetin

期刊：

Toxicon

ISSN：

0041-0101

年：

2024

页码：

107709

DOI：

10.1016/j.toxicon.2024.107709

机构署名：

本校为第一且通讯机构

院系归属：

动物科学与营养工程学院

摘要：

Deoxynivalenol is a widespread feed contaminant that leads to vomit, which results in serious symptom such as increased intestinal permeability and even intestinal mucosal necrosis. Recent studies have reported the role of quercetin in alleviating deoxynivalenol-induced intestinal injury; however, the mechanisms and targets remain unclear. Thus, we aimed to identify the mechanisms of action by using a combination of network pharmacology and molecular docking. We identified 151 quercetin targets, 235 deoxynivalenol targets and 47 porcine intesti...

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Using network pharmacology and molecular docking to uncover the mechanism by which quercetin alleviates deoxynivalenol-induced porcine intestinal injury.

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