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MAPK/NF-κB signaling mediates atrazine-induced cardiorenal syndrome and antagonism of lycopene

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成果类型:
期刊论文
作者:
Jiang, Fu-Wei;Guo, Jian-Ying;Lin, Jia;Zhu, Shi-Yong;Dai, Xue-Yan;...
通讯作者:
Yi Zhao<&wdkj&>Jin-Long Li
作者机构:
[Dai, Xue-Yan; Guo, Jian-Ying; Lin, Jia; Saleem, Muhammad Asmat Ullah; Zhao, Yi; Zhu, Shi-Yong; Li, Jin-Long; Jiang, Fu-Wei] College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China
[Lin, Jia] Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan Polytechnic University, Wuhan 430023, PR China
[Zhu, Shi-Yong] College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, PR China
[Dai, Xue-Yan] Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, PR China
[Zhao, Yi; Li, Jin-Long] Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, PR China
通讯机构:
[Yi Zhao; Jin-Long Li] C
College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China<&wdkj&>Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, PR China<&wdkj&>Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin 150030, PR China
语种:
英文
关键词:
Atrazine;Cardiorenal syndrome;Lycopene;MAPK;NF-κB
期刊:
Science of The Total Environment
ISSN:
0048-9697
年:
2024
卷:
922
页码:
171015
机构署名:
本校为其他机构
院系归属:
动物科学与营养工程学院
摘要:
Atrazine (ATZ) is the most prevalent herbicide that has been widely used in agriculture to control broadleaf weeds and improve crop yield and quality. The heavy use of ATZ has caused serious environmental pollution and toxicity to human health. Lycopene (LYC), is a carotenoid that exhibits numerous health benefits, such as prevention of cardiovascular diseases and nephropathy. However, it remains unclear that whether ATZ causes cardiorenal injury or even cardiorenal syndrome (CRS) and the beneficial role of LYC on it. To test this hypothesis, m...

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