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N-Acetylcysteine improves intestinal function in lipopolysaccharides-challenged piglets through multiple signaling pathways

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成果类型:
期刊论文
作者:
Yi, Dan;Hou, Yongqing*;Xiao, Hang;Wang, Lei;Zhang, Yue;...
通讯作者:
Hou, Yongqing
作者机构:
[Wu, Tao; Hu, Chien-An Andy; Zhang, Yue; Xiao, Hang; Hou, Yongqing; Wang, Lei; Wu, Guoyao; Ding, Binying; Yi, Dan; Chen, Hongbo] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.
[Hu, Chien-An Andy] Univ New Mexico, Dept Biochem & Mol Biol, Sch Med, Albuquerque, NM 87131 USA.
[Wu, Guoyao] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.
通讯机构:
[Hou, Yongqing] W
Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Hubei, Peoples R China.
语种:
英文
关键词:
N-Acetylcysteine;Piglets;Intestinal function;Signaling pathway
期刊:
Amino Acids
ISSN:
0939-4451
年:
2017
卷:
49
期:
12
页码:
1915-1929
基金类别:
This research was jointly supported by National Natural Science Foundation of China (31372319, 31572416, 31402084), the Hubei Provincial Key Project for Scientific and Technical Innovation (2014ABA022), Hubei Provincial Research and Development Program (2010BB023), Hubei Provincial Technology and Innovation Program (2016ABA121), Natural Science Foundation of Hubei Province (2016CFA070), Research and Innovation Initiatives of WHPU (2016J08), the Hubei Hundred Talent Program, Agriculture and Food Research Initiative Competitive Grants (2014-67015-21770) of the USDA National Institute of Food and Agriculture, and Texas AgriLife Research (H-82000). The authors declare that they have no conflict of interest.
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
This study determined whether N-acetylcysteine (NAC) could improve intestinal function through phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR), epithelial growth factor receptor (EGFR), toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB), adenosine 5′-monophosphate-activated protein kinase (AMPK), and type I interferon (IFN) signaling pathways in a piglet model of lipopolysaccharides (LPS) challenge. Thirty-two piglets (24-day-old) were randomly allocated to one of four treatments, with ...

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