APE1 shRNA-loaded cancer stem cell-derived extracellular vesicles reverse Erlotinib resistance in non-small cell lung cancer via the IL-6/STAT3 signalling

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成果类型：

期刊论文

作者：

Tang, Chun-Han;Qin, Ling;Gao, Ying-Chun;Chen, Tai-Yu;Xu, Ke;...

作者机构：

[Tang, Chun-Han; Ren, Tao; Chen, Tai-Yu] Chengdu Med Coll, Clin Med Coll, Chengdu, Peoples R China.

[Qin, Ling] Chengdu Med Coll, Dept Gastroenterol, Clin Med Coll, Affiliated Hosp 1, Chengdu, Peoples R China.

[Gao, Ying-Chun] Pengzhou Peoples Hosp, Oncol Dept, Chengdu, Peoples R China.

[Xu, Ke; Ren, Tao; Liu, Tao] Chengdu Med Coll, Affiliated Hosp 1, Oncol Dept, 278 Middle Sect Baoguang St, Chengdu 610500, Sichuan, Peoples R China.

语种：

英文

关键词：

APE1;cancer stem cells;drug resistance;Erlotinib;extracellular vesicles;interleukin-6;non-small cell lung cancer;short hairpin RNA;signal transducers and activators of transcription 3

期刊：

Clinical and Translational Medicine

ISSN：

2001-1326

年：

2022

卷：

期：

DOI：

10.1002/ctm2.876

基金类别：

Applied Basic Research Program, Science & Technology Department of Sichuan Province [2020YJ0451]; Introduction Foundation of High-level Talents of The First Affiliated Hospital, Chengdu Medical College [CYFY-GQ22]; Special Project of the First Affiliated Hospital, Chengdu Medical College [CYFY2019ZD03]; Cultivation Project of Key Subjects of the First Affiliated Hospital, Chengdu Medical College

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本校为第一机构

摘要：

Collectively, these data indicate that APE1 confers Erlotinib resistance by activating the IL‐6/STAT3 signaling, suggesting targeting APE1 as a possible therapeutic target in Erlotinib‐resistant NSCLC. Abstract Objective Apurinic endonuclease 1 (APE1) has been suggested as an oncogene of lung tumours and our bioinformatics analysis identified the association between Erlotinib resistance and interleukin‐6 (IL‐6). Thus, we performed this work to delineate the mechanistic actions of APE1/IL‐6 signalling in Erlotinib resistance of non‐small c...

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APE1 shRNA-loaded cancer stem cell-derived extracellular vesicles reverse Erlotinib resistance in non-small cell lung cancer via the IL-6/STAT3 signalling

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