期刊论文

Experimental Study on the Anti-Fatigue Effect of Huangqi Jianzhong Decoction on Mice with Cerebral Ischemia

中文

医学理论与实践

1001-7585

2024

37

3

364-366,374

10.19381/j.issn.1001-7585.2024.03.002

S202210496059:湖北省大学生创新创业训练计划项目

本校为第一机构

目的:探讨黄芪建中汤对脑缺血小鼠的抗疲劳作用及初步作用机制.方法:将40 只昆明种小鼠随机分成5 组:对照组、脑缺血模型组、黄芪建中汤低剂量组、黄芪建中汤中剂量组、黄芪建中汤高剂量组,每组 8 只.造模术后第 1天开始给药,黄芪建中汤低、中、高剂量组分别给予生药量为 0.154g/ml、0.308g/ml、0.616g/ml水煎剂0.5ml/d 灌胃,对照组与脑缺血模型组则给予等量生理盐水,给药14d后,观察各组小鼠负重游泳力竭时间、在疲劳转棒仪上停留时间,同时测定小鼠四肢肌力及空腹血糖.结果:与脑缺血模型组比较,给药组小鼠负重游泳时间均明显延长,黄芪建中汤低、高剂量组小鼠在疲劳转棒仪上的停留时间增加,不同剂...

Objective:To explore the anti-fatigue effects and its preliminary mechanism of Huangqi Jianzhong decoction on mice with cerebral ischemia.Methods:40 Kunming mice were randomly divided into 5 groups:control group,cerebral ische-mia model group,Huangqi Jianzhong decoction low dose group,Huangqi Jianzhong decoction medium dose group and Huangqi Jianzhong decoction high dose group,with 8 mice in each group.The administration was started on the first day after modeling,the crude drug dosage of 0.154g/ml,0.308g/ml and 0.616g/ml Huangqi Jianzhong decoction were given 0.5ml/d in the low,medium and hig...