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Holly (Ilex latifolia Thunb.) Polyphenols Extracts Alleviate Hepatic Damage by Regulating Ferroptosis Following Diquat Challenge in a Piglet Model

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成果类型:
期刊论文
作者:
He, Pengwei;Hua, Hongwei;Tian, Wei;Zhu, Huiling;Liu, Yulan;...
通讯作者:
Xu, Xiao
作者机构:
[Hua, Hongwei; Xu, Xiao; He, Pengwei; Liu, Yulan; Tian, Wei; Zhu, Huiling] Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Peoples R China.
通讯机构:
[Xu, Xiao] W
Wuhan Polytech Univ, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan, Peoples R China.
语种:
英文
关键词:
diquat;ferroptosis;holly polyphenols extracts;liver;oxidative stress;weaned piglets
期刊:
FRONTIERS IN NUTRITION
ISSN:
2296-861X
年:
2020
卷:
7
页码:
604328
基金类别:
This research was financially supported by the National Natural Science Foundation of China (No. 31802076), the Project of Innovative Research Groups of the Natural Science Foundation of Hubei Province (No. 2019CFA015), Wuhan Science and Technology Bureau (No. 2018020401011304), and the Open Project of Hubei Key Laboratory of Animal Nutrition and Feed Science (No. 201907).
机构署名:
本校为第一且通讯机构
院系归属:
动物科学与营养工程学院
摘要:
Background: Holly (Ilex latifolia Thunb.) polyphenols extracts (HPE) contain high amounts of polyphenols, including phenolic acids, triterpenoids, tannic acids, and so on, which have strong antioxidant function. This experiment was aimed to explore the protective effect and mechanism of HPE against hepatic injury induced by diquat.Methods: Thirty-two weaned piglets were allotted by a 2 × 2 factorial experiment design with diet type (basal diet vs. HPE diet) and diquat challenge (saline vs. diquat). On the 21st day, piglets were injected with d...

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